Alendronic acid is generally well tolerated, side effects are usually mild and did not require discontinuation of therapy.
In clinical trials, the following side effects occurred with a frequency> 1%:
Gastrointestinal tract: abdominal pain, indigestion, ulcerative disease of the esophagus, dysphagia, flatulence, constipation, diarrhea, acidic eructations, nausea, gastritis, peptic ulcer, including peptic ulcer complicated by bleeding (melena).
Musculoskeletal system: myalgia, pain in the bones, joint pain, muscle cramps.
Nervous system: headache.
In the broad clinical practice, the following side effects have been reported:
Gastrointestinal tract: erosion or ulcers of the esophagus, nausea, vomiting, gastritis, melena, esophagitis, esophageal stricture, perforation, oropharyngeal ulcer, rarely ulcerative diseases of the stomach and duodenum (although there is no connection with the drug), local osteonecrosis of the jaw associated mainly with prior extraction of the tooth and / or local infection (including osteomyelitis), often with slow recovery.
Musculoskeletal system: myalgia, pain in the bones, pain in the joints, rarely - heavy: swelling of the joints, hip fractures.
Skin reactions are rare: skin rash, erythema.
Organism as a whole: hypersensitivity reactions, including urticaria and rarely angioedema, transient symptoms of acute phase reaction at the beginning of treatment (myalgia, malaise, asthenia, rarely - fever), hypocalcemia.Rarely, peripheral edema.
Skin reactions: rash, photosensitivity, itching, alopecia, rarely severe skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis.
Sense organs: rarely - uveitis, scleritis, episcleritis.
Nervous system: dizziness, systemic dizziness, a violation of taste sensations.