Alpizarin - instructions for use, dose, side effects, contraindications

Active substanceTetrahydroxyglucopyranosylxantheneTetrahydroxyglucopyranosylxanthene

Similar drugsTo uncover

Alpisarin®

pills inwards

FARMTSENTR VILAR, ZAO Russia

Alpisarin® ointment

ointment locally externally

FARMTSENTR VILAR, ZAO Russia

Dosage form: & nbsppills

Composition:

Active substance:

Tetrahydroxyglucopyranosylxanthene (Alpisarin®) (in terms of 100% substance) 0.1 g;

Excipients: sugar milk (lactose) - 0.1 g; potato starch - 0.0475 g, calcium stearate (calcium stearic acid) - 0.0025 g.

Description:Tablets are round, flat-cylindrical with a risk on one side and a facet on both sides of a light yellow color with a greenish tinge or without a shade to yellow with a greenish tinge or without a shade with darker patches.

Pharmacotherapeutic group:An antiviral agent.

ATX: & nbsp

J.05.A.X Other antiviral drugs

Pharmacodynamics:

Alpizarin® is obtained from mangiferin, isolated from mango leaves of Indian - Mangifera indica L., family of sumahovyh - Anacardiaceae. Pharmacodynamics. Alpisarin® has antiviral activity against viruses: Herpes simplex 1 and 2 types, Herpes zoster, Varicella zoster, cytomegalovirus. In the experiments in vitro shows the inhibitory effect of tetrahydroxyglucopyranosylxanthene against the human immunodeficiency virus.

The inhibitory effect of the drug on the reproduction of the virus is especially evident in the early stages of its development. Alpisarin® does not affect the activity of viral neuraminidase.

Alpisarin® has immunostimulating properties with respect to cellular and humoral immunity, the ability to induce gamma-interferon production in blood cells.

Alpisarin® inhibits the growth of Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus, Mycobacterium tuberculosis) bacteria, fungi (Microsporum canis) and pathogenic protozoa (Entamoeba histolytica, Trichomonas vaginalis). The mechanism of action of the drug is based on the ability to suppress the activity of bacterial nuclease. Alpisarin® has a moderate anti-inflammatory effect.

Pharmacokinetics:

The drug, when taken orally, is rapidly absorbed from the gastrointestinal tract. In the blood plasma unchanged tetrahydroxy-glucopyranosylxanthene is determined within 0.5-5 h after application. The maximum concentration of tetrahydroxyglucopyranosylxanthene is 4.5, μg / ml is achieved 1 hour after its application. Tetrahydroxyglucopyranosylxanthene is largely associated with blood proteins (90-70%).

Pre-adrenal ways of excretion of tetrahydroxyglucopyranosyl-xanthene predominate. Excretion of unchanged tetrahydroxyglucopyranosylxanthene by the kidneys within 24 hours does not exceed 0.1%.

Indications:

In the combination therapy of acute and recurrent infections caused by the herpes simplex virus of different localization (including genital); viral diseases of the oral mucosa (aphthous stomatitis), shingles, herpeticiform eczema Kaposi, cytomegalovirus infection, chicken pox.

Contraindications:

Hypersensitivity to the components of the drug. Pregnancy. Children under 3 years. Insufficiency of lactase, lactose intolerance, glucose-galactose malabsorption.

Carefully:the period of breastfeeding.

Pregnancy and lactation:

Data on the isolation of tetrahydroxyglucopyranosylxanthrene in breast milk are not available, so the use of the drug during breastfeeding is possible only according to vital indications if the intended benefit to the mother exceeds the potential risk for the child. Consultation of the doctor is necessary.

Dosing and Administration:

Tablets are used regardless of food intake. Adults and children over 12 years of age are prescribed 1-2 tablets 3-4 times a day, children 6-12 years - 1 tablet 2-3 times a day, children 3-6 years old - ^1/2-1 tablet 2-3 times a day.The therapeutic effect of the drug is most pronounced when it is prescribed in the initial period of the disease. The duration of treatment depends on the form and severity of the disease:

- In the case of common rashes in acute and recurrent forms of herpes simplex as genital as well as extragenital localization, as well as in the presence of fever, lymphadenopathy and other common phenomena, the drug is used for 5-14 days.

- With keposi herpetiform eczema and cytomegalovirus infection - within 7-21 days as part of complex therapy.

- With aphthous stomatitis, the drug is prescribed for 5-15 days.

- In diseases caused by Herpes zoster (shingles) and Varicella zoster (chicken pox) - for 5-21 days.

When relapses, repeated courses of treatment with the drug are carried out. To prevent the recurrence of herpesvirus infections, the drug is prescribed one month after the end of treatment for 10-14 days.

The maximum daily dose of the drug for children from 3 to 12 years is 300 mg (three tablets); for children over 12 years of age and adults - 800 mg (eight tablets).

Side effects:Allergic reactions are possible.

Overdose:

To date, cases of overdose have not been reported.The occurrence of an overdose is unlikely.

Interaction:

Not described.

Special instructions:

- In the case of common rashes, as well as in the presence of fever, lymphadenopathy and other common phenomena, the drug "Alpisarin® tablets 100 mg" is used in conjunction with the drug "Alpizarin® ointment for external and topical application of 2% and 5%",

- 1 tablet of the preparation contains 0.1 g of milk sugar (lactose) and 0.0475 g of potato starch, which corresponds to 0.01 XE (bread units). The maximum daily dose of the drug for children from 3 to 12 years old contains 0.03 XE; for children over 12 years of age and adults - 0.08 HU.

Effect on the ability to drive transp. cf. and fur:The drug has no effect on the performance of potentially hazardous activities or requiring increased concentration of attention and speed of psychomotor reactions (transport management and work with moving mechanisms).

Form release / dosage:

Tablets of 100 mg.

For 10, 20, 30 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil with thermal lacquer coating.

2 contour cell packs No. 10, or 1 contour pack No. 20 or No. 30, together with a medical instruction, are placed in a pack of cardboard for consumer containers.

Packaging:(10) - contour mesh package (2) / 2 contourcell packagings No. 10 together with instructions for use / - Cardboard pack
(20) - contour mesh package (1) / 1 contour pack No. 20 together with instructions for use / - Cardboard tutu
(30) - contour cell packaging (1) / 1 contourcell No. 30 together with instructions for use / - Cardboard package

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:5 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LP-000946

Date of registration:18.10.2011

The owner of the registration certificate:FARMTSENTR VILAR, ZAO FARMTSENTR VILAR, ZAO Russia

Manufacturer: & nbsp

FARMTSENTR VILAR, ZAO Russia

Information update date: & nbsp26.09.2015

Illustrated instructions

Instructions

Alpisarin® (Alpisarin®)