Ammifurin® (Ammifurin®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceAmmi large fruit furokumarinyAmmi large fruit furokumariny
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  • Ammifurin®
    solution externally 
    FARMTSENTR VILAR, ZAO     Russia
    • Dosage form: & nbspsolution for external use
    Composition:

    Active substance:

    Ammifurin® 0.3 g (ammonium large fruit amount of furocoumarins) (in terms of 100% substance)

    Excipients: Ethyl alcohol 95% - 74 ml (ethanol 95%)

    Glycerol-13 ml

    Purified water - up to 100 ml

    Description:

    Transparent, light yellow with a greenish hue of color, liquid, with the smell of alcohol, is sensitive to light.

    Pharmacotherapeutic group:Photosensitizing agent of plant origin
    ATX: & nbsp

    D.05.A   Preparations for the treatment of psoriasis for external use

    Pharmacodynamics:

    Ammifurin® is the sum of furocoumarins: isopimpinelline, bergapten and xanthate toxin isolated from ammonium large-ammonium- Ammi majus L, family of celery (umbrella) - Apiaceae (Umbelliferae).

    Ammifurin® has a photosensitizing effect.

    Indications:

    Ammifurin® is used in adults with vitiligo, nest and total baldness, psoriasis.

    Contraindications:

    Intolerance to UFOs and psoralens, diseases accompanied by hypersensitivity to light (albinism, systemic lupus erythematosus, etc.), in combination with UFD with the following diseases: tuberculosis, thyrotoxicosis,diseases of the blood, liver, kidneys, cardiovascular system, hypertension II-III degree, diseases of the central nervous system, diabetes, pregnancy, lactation, cataracts, multiple pigment nevi, benign and malignant tumors.

    Dosing and Administration:

    Ammifurin® is administered in combination with ultraviolet irradiation (UFV). Ammifurin® solution is applied externally, applying to the lesions for 1 hour before irradiation.

    In common forms of the disease, the external application of the drug is combined with its ingestion.

    With psoriasis, the procedures are carried out 4 times a week. UV irradiation starts with 1/2 biodoside, gradually increasing to 5-6 biodosomes, which corresponds (depending on the individual sensitivity of the patient to UV radiation) the duration of irradiation from 1-2 minutes to 10-15 minutes. The total amount of irradiation is 15-20 procedures. Treatment of patients with psoriasis can be carried out in combination with long-wave UV radiation.

    With vitiligo, nest and total baldness irradiation is carried out 3 times a week (every other day) - 20-25 irradiations. A total of 4-6 courses.

    Patients with limited foci of Ammifurin® are given only externally in the form of a 0.3% solution followed by UFO. The lesion is smeared with 0.3% Ammifurin® solution 1 hour before irradiation. The procedures are carried out 3-4 times a week. UFOs start with 1/2 biodoside, gradually increase to 5-6 biodosomes. The number of procedures depends on the results of treatment and constitute a total of 20-25 exposures. In the summer, irradiation with a quartz lamp can in all cases be replaced by a dosed solar insolation.

    The course dose of Ammifurin® 1-2 vials of 0.3% solution of 50 ml (0.15-0.3 g). Repeated courses are conducted at intervals of 1-1.5 months.

    Side effects:

    Secondary skin pigmentation, mild erythema, itching.

    Overdose:

    When an overdose of solar and artificial UV radiation can there is acute dermatitis (erythema, edema, possible blisters). In this case, treatment should be stopped before the resolution of the phenomena of dermatitis.

    Interaction:

    Strengthens the effect of other photosensitizers (including photosensitizing foods and cosmetics).

    This therapy can be carried out against the background of the generally accepted drug treatment, which includes the use of penicillin, lidase, vascular drugs, and external agents.

    Special instructions:

    - Care should be taken when using products and cosmetics containing photosensitizing substances.

    - To avoid irradiation of the apparently healthy skin surrounding the scleroderma foci, when applied locally, it is lubricated, at a distance of 1-2 cm from the boundaries of the lesion, with zinc paste or a photoprotective cream. After the procedure, the zinc paste is removed with a cotton swab dipped in vegetable oil.

    - In common forms of the disease, the external application of Ammifurin® solution is combined with its ingestion in the form of 20 mg tablets. The drug is used after eating, washed down with milk, at a dose of 0.8 mg / kg, but not more than 80 mg per reception, once, 2 hours before UFO.

    Form release / dosage:

    Solution for external use 0,3%.

    Packaging:

    50 ml and 100 ml in bottles of orange glass with a screw neck, sealed with plastic caps and plastic screw caps.

    To 50 ml in imported bottles of dark glass with a screw mouth, closed with a plastic cap screwed on with a control ring, equipped with a gasket.

    Each bottle of 50 ml and 100 ml, together with the instruction for medical use, is placed in a pack of cardboardfor consumer packaging.

    For 1000 ml and 5000 ml in bottles of orange glass, sealed with lids with gaskets.

    Storage conditions:

    In the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    5 years. Do not use the product after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-001964/07
    Date of registration:07.08.2007
    Expiration Date:Unlimited
    The owner of the registration certificate:FARMTSENTR VILAR, ZAO FARMTSENTR VILAR, ZAO Russia
    Manufacturer: & nbsp
    Information update date: & nbsp18.08.2017
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