Amoxicillin
Has bactericidal action due to inhibition of bacterial cell wall synthesis. Violates synthesis biopolymer peptidoglycan - the main component of the bacterial cell wall. It inhibits the peptidoglycan transpeptidase, inhibits the activity of the endogenous inhibitor, which leads to activation of murein hydrolase, which cleaves peptidoglycan. Effective against fissile bacteria, in the walls of which the synthesis of peptidoglycan occurs.
A semi-synthetic antibiotic with a broad spectrum of action from the penicillin group is destroyed by the action of β-lactamases.
Has a bactericidal effect against gram-negative bacteria: Acinetobacter spp., Moraxella catarrhalis, Citrobacter spp. (including Citrobacter freundii, Citrobacter diversus, Citrobacter amalonaticus), Enterobacter spp., Escherichia coli, Haemophilus influenzae, Klebsiella spp. (including Klebsiella pneumoniae), Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitidis, Proteus mirabilis, Proteus vulgaris, Providencia rettgeri, Providencia stuartii, Pseudomonas spp. (at including Pseudomonas aeruginosa, Pseudomonas maltophilia), Salmonella spp., Serratia spp. (including Serratia marcescens); gram-positive bacteria: Staphylococcus aureus, Staphylococcus epidermidis (coagulase-negative strains), Staphylococcus saprophyticus, Streptococcus agalactiae (group B), Streptococcus bovis, Enterococcus faecalis, Streptococcus pneumoniae, Streptococcus pyogenes (group A, beta-hemolytic), Streptococcus viridans; anaerobic bacteria: Bacteroides spp., including Bacteroides fragilis group (Bacteroides fragilis, Bacteroides vulgatus, Bacteroides thetaiotaomicronron, Bacteroides ovatus, Bacteroides distasonis) and non-Bacteroides fragilis (beta-melanogenic), Clostridium spp. (including Clostridium perfringens, Clostridium difficile, Clostridium sporogenes, Clostridium ramosum, Clostridium bifermentans), Eubacterium spp., Fusobacterium spp. (including Fusobacterium nucleatum and Fusobacterium necrophorum), Peptococcus spp., Peptostreptococcus spp., Veillonella spp.
Sulbactam
It has no clinically significant effect, but, having a β-lactam structure associated with penicillins, competitively inhibits β-lactamase, preventing the inactivation of amoxicillin and expanding its spectrum of activity. It shows bactericidal activity against Neisseriaceae and Acinetobacter.