The dosage regimen is set individually, depending on the severity of the course and localization of the infection, the sensitivity of the pathogen. Treatment should be continued for at least another 2-3 days after the disappearance of the clinical symptoms of the disease, but no more than 14 days.
In the treatment of infections caused by beta-hemolytic streptococci, the drug is recommended to apply for at least 10 days.
The drug is administered intramuscularly, intravenously, injectively or intravenously infusion.
Doses are given in terms of amoxicillin:
The usual recommended dose for adults and children over 12 years of age: Enter 1.0 g 2-3 times a day;
For the prevention of postoperative infections in operations lasting less than 1 hour during introductory anesthesia, the drug is administered intravenously at a dose of 1.0 g.
With longer operations - 1.0 g every 6 hours during the day. With a high risk of infection, administration can be continued for several days.
For children from 6 to 12 years: 500 mg 3 times a day;
For children from 2 to 6 lept, 250 mg 3 times a day;
For children under 2 years: 40-60 mg / kg 2-3 times a day;
In severe infections, the daily dose of the drug (in terms of amoxicillin) can be increased to 100 mg / kg / day, especially caused by gram-negative pathogens.
Patients with impaired renal function:
The dosage regimen is changed depending on the creatinine clearance of the CCJ.
With QC greater than 30 ml / min, a change in the dosing regimen is not required; with CC 10-30 ml / min, treatment is initiated with on / in the 1.0 g, followed by 500 mg / 2 times per day; with CC less than 10 ml / min - 1.0 g, then 500 mg / day iv once a day.
Hemodialysis reduces the concentration in the blood plasma, and therefore during and at the end of dialysis is further added with 500 mg drug / in.
In children with chronic renal failure, the usual single doses are used, increasing the intervals between administrations, as indicated for adults.
Method of preparation of solutions:
For the / m introduction to the contents of the vial (500 mg + 250 mg or 1000 mg + 500 mg) is added 5 ml of water for injection.
Use freshly prepared solutions.
For intravenous administration a single dose is dissolved in a 0.9% solution NaCl or 5% dextrose (glucose) solution in a volume of 10 ml (for IV injection) to 100 - 200 ml (for IV infusion introduction).
For intravenous infusion dilution is possible with lactated Ringer's solution.
When diluted with lactated Ringer's solution, the solution is prepared in 2 stages: first, sterile water for injection is used, then the resulting solution is diluted with a lactated Ringer's solution.
With iv injection the prepared solution is introduced slowly.
With IV infusion introduction the prepared solution is slowly added dropwise for 15-60 minutes.