Depending on the chosen dose and the severity of the infection, Anaerocef® can be administered intravenously (either jetwise or intravenously) or in / m.
For adults, the average therapeutic dose is 1-2 g every 6-8 hours. In uncomplicated urinary tract infections - in / m, 1 g 2 times a day. With uncomplicated gonorrhea, incl. caused by penicillinase-producing strains Neisseria gonorrhoeae, injected once / in a dose of 2 g; At the same time (or 1 hour later) 1 g of probenecid is ingested. In severe infections, the IV route is preferred; appoint 2 g every 4 hours or 3 g every 6 hours. The daily dose should not be more than 12 g. Cefoxytin is excreted from the body mainly by the kidneys, therefore, in patients with renal insufficiency, correction of the administration regimen is required depending on the values of creatinine clearance (see Fig.table):
Dosing of Anaerocepha in patients with renal insufficiency
| Creatinine clearance, ml / min | Dose, g | Interval between doses |
| 30-50 | 1-2 | 8-12 hours |
| 10-29 | 1-2 | 12-24h |
| 5-9 | 0,5-1 | 12-24h |
| <5 | 0,5-1 | 24-48 h |
Patients, to the on hemodialysis, it is recommended that after each procedure of hemodialysis additionally introduce 1 -2 g of Anaeroceph®.
Children over 1 month Anaerocef® is administered at a rate of 30-40 mg / kg every 6-8 hours (the maximum daily dose should not exceed 12 g). With mild and moderate infections, intramuscular injection is possible, with severe infections, intravenous injections or infusion of the drug are preferred. In children under 3 months, Anaerocef® is administered only intravenously.
Newborns of the first week of life and premature newborns weighing more than 1500 g are administered intravenously in a single dose of 30-40 mg / kg every 12 hours; newborns 1-4 weeks of life at 30-40 mg / kg intravenously every 8 hours.
Adults for the prevention of postoperative infectious complications is administered iv in a dose of 2 g for 30 min before the operation; according to the indications, in the first day of the postoperative period, 2 g every 6 hours.
In the operation of a cesarean section, 2 g of Anaerosceph® is administered IV immediately after the umbilical cord is clamped.
Newborns and children up to 12 years, Anaerocef® is administered iv 30 minutes before the start of the operation at a dose of 30-40 mg / kg. According to the indications, in the first day of the postoperative period, the drug is additionally administered in a dose of 30-40 mg / kg every 6-8 hours (in newborns - 8-12 hours).
Preparation of solutions, methods of administration
Do not use solutions containing preservatives (for example, benzyl alcohol in bacteriostatic water for injection) for the preparation of Anaerocetef® solutions used in neonates. For IV injection, it is recommended to dissolve 1 g of Anaerocepha ® in 10 ml of water for injection. The resulting solution should be administered intravenously slow within 3-5 minutes; it is possible to administer a system for intravenous infusion through the injection unit for transfusion of compatible solutions (see "Interaction with Other Drugs"). When using a long intravenous infusion 1 g Anaerocef® is dissolved in 3-5 ml of sterile water for injection; after complete dissolution, the resulting solution is added to 200-400 ml of a compatible infusion medium: 0.9% sodium chloride solution, 5% dextrose solution, an aqueous solution containing 5% dextrose and 0.9% sodium chloride; injected intravenously drip using a system for intravenous infusion.To prepare the solution for intramuscular injection, 1 g of Anaerotsefa® is dissolved in 2-3 ml of one of the following solvents: water for injection, 0.5% lidocaine hydrochloride solution, 1% lidocaine hydrochloride solution. Enter by a deep injection into the area with a pronounced muscle layer (upper-outer quadrant of the buttock), after having conducted an aspiration test to avoid insertion into the blood vessel.