Intravenous (bolus or infusion), intramuscularly.
Average Adult Dose - 1-2 g every 6-8 hours.
In uncomplicated urinary tract infections - intramuscularly, 1 g 2 times a day.
With uncomplicated gonorrhea, incl. caused by penicillinase producing strains, intramuscularly 2 g once, simultaneously (or 1 hour later) with ingestion of 1 g of probenecid.
In severe infections, intravenously, 2 g every 4 hours or 3 g every 6 hours. The daily dose may be increased to 200 mg / kg (but not more than 12 g).
If there is a violation of the excretory function of the kidneys, the first dose is 1-2 g, in the future it is necessary to reduce the single dose and increase the intervals between the administrations.
In patients with impaired renal function, the dosage regimen of cefoxitin is set depending on the creatinine clearance.
| Creatinine clearance (ml / min) | Dosing regimen |
| 30-50 | 1-2 g every 8-12 h |
| 10-29 | 1-2 g every 12-24 h |
| 5-9 | 0.5-1 g every 12-24 hours |
| Less than 5 | 0.5-1 g every 24-48 h |
Patients on hemodialysis are advised to add 1-2 g after each hemodialysis procedure. In children with renal dysfunction, correction of the dosing regimen (reduction of the single dose and increase in the interval between doses) is performed according to recommendations for adult patients with impaired renal function.
Children - in a single dose of 30-40 mg / kg; the frequency of administration depends on the age: premature infants with a body weight of more than 1500 g and a newborn in the first week of life - after 12 hours; Newborns 1-4 weeks of life - after 8 hours; children, older than 1 month - after 6 or 8 hours. The maximum daily dose for children should not exceed 12 g.
For the prevention of postoperative infections, adults are prescribed 2 g intramuscularly or intravenously 0.5-1 h before the operation; after the operation - 2 g every 6 hours for 1 day. Children - 30-40 mg / kg with the above intervals, but the newborn second and third dose is administered after 8-12 hours. When conducting cesarean section - one-time, intravenously, 2 g after clamping the umbilical cord.
Preparation of solutions for injection:
For intramuscular injection, 500-1000 mg of the drug is dissolved in 2 ml of water for injection or 0.5-1% of a solution of lidocaine (without epinephrine).
For intravenous bolus administration, 500 mg of the drug is dissolved in 5 ml of water for injection, 1000 mg in 10 ml of water for injection. Introduction is carried out slowly, within 3-5 minutes.
For intravenous infusion, 500 mg of the drug is dissolved in 50 ml of the solvent, 1000 mg in 100 ml of the solvent. As a solvent, 0.9% solution of sodium chloride or 5% solution of dextrose. The duration of the infusion is 30-60 minutes.