Anauran - instructions for use, dose, side effects, contraindications

Active substanceLidocaine + Neomycin + Polymyxin BLidocaine + Neomycin + Polymyxin B

Similar drugsTo uncover

drops tion.

Dosage form: & nbsptoApli ears

Composition:

Per 100 ml:

active substances: polymyxin B sulfate - 1000000 ME, neomycin sulfate 0.5 g (equivalent to 375,000 ME), lidocaine hydrochloride 4.0 g;

Excipients: benzalkonium chloride - 0.01 g, propylene glycol - 44 ml, glycerol - 26.5 g, water purified to 100 ml.

Description:

Transparent, colorless liquid, odorless.

Pharmacotherapeutic group:Antibiotic combined (antibiotics: aminoglycoside + polypeptide cyclic + local anesthetic)

ATX: & nbsp

S.02.A.A.30 Combination of antimicrobials

Pharmacodynamics:

Combination agent for topical application, renders antibacterial and local anesthetic effect.

Pharmacodynamics

Neomycin sulfate is an aminoglycoside antibiotic of broad spectrum, acts bactericidal against Gram-positive (Staphylococcus spp., Streptococcus pneumoniae) and Gram-negative (Escherichia coli, Shigella dysenteriae spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Proteus spp.) of microorganisms; in a relationship Streptococcus spp. - Low active.

Polymyxin B is a polypeptide antibiotic. Active against gram-negative microorganisms: Escherichia coli, Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Salmonella typhi and Salmonella paratyphi; Pseudomonas aeruginosa. Is active against Proteus spp., Mycobacterium spp., Gram-positive cocci, fungi. Has a weak local irritant effect.

Lidocaine - a local anesthetic, quickly eliminates pain and itching.

Pharmacokinetics:

Pharmacokinetic studies were not carried out, because The drug is intended for topical administration and systemic effects are unlikely.

Indications:

Acute and chronic otitis externa, middle acute otitis at the stage before perforation, chronic exudative otitis media; postoperative purulent complications after radical mastoidectomy, tympanoplasty, anthotomy, fenestration.

Contraindications:

Hypersensitivity to one of the components of the drug.

Pregnancy and lactation:

During pregnancy and lactation, as well as in children under 1 year of age, the drug should be used only in case of emergency and under the supervision of a doctor.

Dosing and Administration:

Locally, into the external ear canal with a special pipette. After digging for a few minutes, keep your head tilted.

Adults: 4-5 drops 2-4 times a day, children: 2-3 drops 3-4 times a day, depending on the severity of the disease.

The course of treatment should not exceed 7 days.

Side effects:

There are local allergic reactions: hyperemia, itching and flaking of the skin of the external auditory canal, which disappear without treatment, after the drug is discontinued.

Systemic effects are unlikely due to low doses of the drug used. However, with prolonged treatment, systemic effects, in particular ototoxicity and nephrotoxicity due to neomycin absorption, are possible.

Overdose:

Cases of overdose are not described in the literature.

Interaction:

Incompatible with monomycin, streptomycin, gentamycin, amikacin, netilmicin (possible to increase the ototoxic effect of the above antibiotics).

Special instructions:

Anauran® is used exclusively for ear disorders. In severe and persistent infections, local treatment should be supplemented with systemic use of antibiotics.

Long-term use of Anauran®, as well as other antibiotics, can lead to the development of superinfection with drug-resistant microorganisms.

Form release / dosage:

Ear drops.

Packaging:

To 25 ml in a bottle of dark glass with a lid-dropper made of polyethylene with the control of the first opening.

One bottle with instructions for medical use is placed in a pack of cardboard.

Storage conditions:

At a temperature of 15 ° C to 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

After opening the vial the drug can be used for 3 months.

Terms of leave from pharmacies:On prescription

Registration number:П N012942 / 01

Date of registration:30.04.2008

Expiration Date:Unlimited

The owner of the registration certificate:Zambon SpAZambon SpA Italy

Manufacturer: & nbsp

ZAMBON, S.p.A. Italy

Representation: & nbspZAMBON SpA ZAMBON SpA Italy

Information update date: & nbsp01.09.2017

Illustrated instructions

Instructions

Anauran® (Anauran®)