Anti-Angin® Formula (Anti-Angin® Formula)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspspray for topical use
Composition:

Composition per 1 dose / per 100 g:

Active substances:

Chlorhexidine bigluconate 0.24 mg / 0.120 g in the form of a 20% solution of chlorhexidine Bigluconate 1.20 mg / 0.600 g

Tetracaine hydrochloride - 0.12 mg / 0.060 g

Excipients: glycerol 85% - 60.00 mg / 30.00 g, ethanol 96% - 80.00 mg /40.00 g, aspartame - 0.20 mg / 0.10 g, flavoring mint - 2.00 mg / 1.00 g, propyl parahydroxybenzoate 0.20 mg / 0.10 g, citric anhydrous acid - 0.02 mg / 0.01 g, purified water - up to 200 mg / 100 g.

Description:

Spray in a plastic vial with a dosing valve. The contents of the bottle are a colorless liquid with the smell of mint.

Pharmacotherapeutic group:Antiseptic + local anesthetic
ATX: & nbsp
  • Other drugs
    • Pharmacodynamics:
    Chlorhexidine can have bactericidal and bacteriostatic effects.

    Has a broad antibacterial spectrum of action against Gram-positive and Gram-negative bacteria, is active against Candida albicans. Chlorhexidine is especially active in Streptococcus mutans, Streptococcus salivarius, Escherichia coli and anaerobic bacteria. Less effective against such microorganisms as Streptococcus spp., Proteus spp., Pseudomonas, Klebsiella spp., Veillonella spp.

    Tetracaine has a local anesthetic effect.

    Pharmacokinetics:

    Tetracaine is easily and completely absorbed through the mucous membranes.The binding with plasma proteins is high. Completely hydrolyzed by cholinesterase for 1-2 hours with the formation of para-aminobenzoic acid compounds. It is excreted by the kidneys and with bile, while it is partially subjected to hepatic intestinal recirculation.

    There are no clinical data on the absorption of chlorhexidine through the mucous membrane of the human mouth. Chlorhexidine can persist in saliva up to 8 hours. Virtually not absorbed from the gastrointestinal tract. It is excreted primarily through the intestine (90%), less than 1% is excreted by the kidneys.

    Indications:

    Prevention, etiotropic and symptomatic treatment of infectious and inflammatory diseases of the oral cavity and pharynx caused by sensitive to chlorhexidine microorganisms (pharyngitis, tonsillitis, the initial stage of angina, periodontitis, stomatitis, gingivitis, condition after tonsillectomy or tooth extraction, etc.). Complex therapy of angina (used at the first signs of the disease - with pain in the throat and persheniya).

    Contraindications:

    Hypersensitivity to the components of the drug, damage or inflammation of the mucous membranes, in the highly vascularized areas, phenylketonuria, children's age (up to 10 years).

    Carefully:In pregnancy and lactation, diabetes, glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, oxalose and urolithiasis.
    Pregnancy and lactation:

    Only after consulting a doctor.

    Dosing and Administration:

    Locally. The drug is sprayed on the mucous membrane of the mouth and throat when breathing is delayed.

    Adults and children over 15 years: 1-2 injections at the reception up to 6 times a day.

    Children from 10 to 15 years: 1-2 injections at the reception up to 3 times a day.

    The course of treatment is not more than 5 days.

    Side effects:Allergic reactions, burning of the mucous membrane of the mouth.
    Overdose:

    Overdose Symptoms: dizziness, general weakness, cyanosis, agitation, restlessness, muscle tremor, respiratory failure, nausea, vomiting.

    Treatment: gastric lavage, the appointment of salt laxatives; symptomatic therapy.

    Interaction:

    Sucrose, polysorbate 80, insoluble salts of magnesium, zinc and calcium reduce the effect of chlorhexidine.

    Tetracaine reduces the antibacterial activity of sulfanilamide preparations. Vasoconstrictors prolong the effect and reduce toxicity.Drugs that inhibit cholinesterase (antimiasthenic drugs, cyclophosphamide, thiotepa and others), reduce the metabolism of tetracaine and increase its toxicity. Anticoagulants (dalteparin sodium, sodium enoxaparin, heparin sodium, warfarin) increase the risk of bleeding. When using tetracaine with drugs that inhibit monoamine oxidase (furazolidone, procarbazine, selegiline), the risk of lowering blood pressure increases. Tetracaine enhances and lengthens the effect of myorelaxing drugs. Beta-adrenoblockers slow the metabolism of tetracaine, increasing its toxicity (decreased hepatic blood flow).

    Special instructions:

    The spray should not be inhaled. Avoid contact with the eyes.

    If after 3 days after the start of treatment the symptoms of the disease do not disappear or the deterioration of the course of the disease is observed, it is necessary to determine the expediency of its further application.

    Children can use the drug from the age of 10, while the child should be able to hold his breath when injecting the drug.

    When taking the drug must take into account that 1 dose (1 injection) contains 83 mg of absolute ethanol.

    It is not recommended to use simultaneously with oral and throat preparations containing iodine (Lugol's solution, povidone-iodine).

    Effect on the ability to drive transp. cf. and fur:The drug should be taken no later than 30 minutes before the start of driving. If this recommendation is observed, the drug does not affect the ability to drive vehicles and control mechanisms.
    Form release / dosage:

    Spray for topical use dosed.

    Packaging:For 25 ml of the drug (100 doses) is placed in a plastic bottle with a dosing valve in a cardboard box with instructions for use.
    Storage conditions:

    At a temperature of no higher than 25 ° C.

    Keep out of the reach of children!

    Shelf life:

    2 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-007742/10
    Date of registration:06.08.2010 / 13.03.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:VALEANT, LLC VALEANT, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp06.09.2017
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