Argdied® (Argedin®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceSulfadiazine silverSulfadiazine silver
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  • Argdied®
    cream externally 
    Boznalek, AO     Bosnia and Herzegovina
    • Dosage form: & nbspCream for external use.
    Composition:
    1 g of cream contains
    Active substance: Sulfadiazine silver-10.00 mg / g
    Excipients: Vaseline 145.00 mg, propylene glycol 100.00 mg, cetomacrogol1000-87.00 mg, paraffin liquid 58.00 mg, methyl parahydroxybenzoate 1.00 mg, water purified 599 mg.

    Description:
    Cream from white to light yellow color.

    Pharmacotherapeutic group:Antimicrobial agent, sulfonamide.
    ATX: & nbsp

    D.06.B.A   Sulfonamides

    Pharmacodynamics:
    Sulfanilamide preparation for external use. Has a broad spectrum of antibacterial action, which includes virtually all Gram-positive and Gram-negative microorganisms, including Pseudomonas aeruginosa, Escherichia coli, Proteus spp., Staphytococcus spp., Streptococcus spp., Enteiobacter spp. and Klebsiella spp., some species of fungi and yeast are also sensitive to it.
    When applied to damaged skin, it dissociates with the release of silver and sulphanilamide ions, interacts with the sulfhydryl groups of the enzymes of the bacterial cell and reduces their activity, while at the same time it does not have a damaging effect on tissue cells. Penetrates into a necrotic tissue. It acts bacteriostatically.
    Pharmacokinetics:When applied to the wound surface, approximately 10% of sulfadiazine and 1% of silver are absorbed into the peripheral and systemic bloodstream.Application to the extensive wound surface is accompanied by an increase in the concentration of sulfadiazine in the blood to 10-20 μg / ml. The elimination half-life is 10 hours.
    Indications:Infected, superficial wounds and burns with mild exudation, pressure sores, trophic and long-term healing ulcers (including stump wounds), abrasions, skin graft.
    Contraindications:
    Allergic reactions to drug components, suppression of bone marrow hematopoiesis, deficiency of glucose-6-phosphate dehydrogenase, renal / hepatic insufficiency, porphyria, deep purulent wounds and burns with pronounced exudation, children under 2 years.
    Pregnancy and lactation:
    Application in pregnancy is possible only in cases where the expected benefit of therapy for the mother exceeds the potential risk to the fetus. In such cases, the drug should be used as short as possible and limited to small areas of skin.
    If it is necessary to use lactation, breastfeeding should be discontinued.
    Dosing and Administration:Outwardly. For adults and children over 2 years old, a damaged surface after cleaning the wound is greased with a layer of cream 2 mm 2 times a day; largedamaged skin surfaces are closed with a sterile dressing, replaceable 2 times a day, in serious cases up to 4 times. When changing dressings, pain effects are not observed. Before each re-application it is necessary to remove the previous layer of the preparation with a water jet or antiseptic solution. The course of treatment continue until healing.
    Side effects:Burning, itching, brownish-gray coloration of the skin, skin allergic reactions (skin rash, photosensitivity); with long-term use on large wound surfaces - systemic side effects (leukopenia, headache, dyspepsia).
    Interaction:Tzimitidine - increases the risk of developing leukopenia.
    Special instructions:Silver salts, reacting with air oxygen, metals and other chemical components, especially with catalyzing thermal effects, darken, so the drug should be stored in a closed container and away from heat sources. Parts of the body treated with the drug are recommended to protect from direct sunlight.
    Effect on the ability to drive transp. cf. and fur:Does not affect.
    Form release / dosage:Cream for external use 1%.
    Packaging:For 40 g of the drug in an aluminum tube.The tube opening is protected by a membrane. The tube is closed with a lid of polypropylene and polyethylene. Each tube with instructions for use is placed in a cardboard box.
    Storage conditions:At a temperature of no higher than 25 ° C. Keep out of the reach of children.
    Shelf life:2 years. Do not use after the expiration date.
    Terms of leave from pharmacies:On prescription
    Registration number:LP-001040
    Date of registration:21.10.2011
    The owner of the registration certificate:Boznalek, AOBoznalek, AO Bosnia and Herzegovina
    Manufacturer: & nbsp
    BOSNALIJEK, d.d. Bosnia and Herzegovina
    Representation: & nbspBOSNALEK AO BOSNALEK AO Bosnia and Herzegovina
    Information update date: & nbsp27.08.2015
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