Included in the formulation
АТХ:D.06.B.A Sulfonamides
Pharmacodynamics:Sulfanilamide preparation for external use. It acts bacteriostatically. Has a broad spectrum of antibacterial action, which includes virtually all Gram-positive and Gram-negative microorganisms, including Pseudomonas aeruginosa, Escherichia coli, Proteus spp., Staphylococcus spp., Streptococcus spp., Enteiobacter spp. and Klebsiella spp., some species of fungi and yeast are also sensitive to it.
When applied to damaged skin, it dissociates with the release of silver and sulphanilamide ions, interacts with the sulfhydryl groups of the enzymes of the bacterial cell and reduces their activity, while at the same time it does not have a damaging effect on tissue cells. Penetrates into a necrotic tissue.
Pharmacokinetics:When applied to the wound surface, approximately 10% of sulfadiazine and 1% of silver are absorbed into the peripheral and systemic bloodstream. Application to the extensive wound surface is accompanied by an increase in the concentration of sulfadiazine in the blood to 10-20 μg / ml. Half-life 10 hours.
Indications:- infected, superficial wounds and burns with mild exudation;
- pressure sores;
- trophic and long-term healing ulcers (including stump wounds);
- abrasions;
- Skin transplantation.
IX.I80-I89.I83.2 Varicose veins of the lower extremities with ulcer and inflammation
XII.L80-L99.L89 Decubital ulcer
XIX.T08-T14.T14.0 Superficial injury of unspecified area of the body
XIX.T20-T32.T30 Thermal and chemical burns, unspecified
XIX.T79.T79.3 Post-traumatic wound infection, not elsewhere classified
XXI.Z80-Z99.Z94 Presence of transplanted organs and tissues
Contraindications:- Allergic reactions to the components of the drug, oppression of bone marrow hematopoiesis;
- deficiency of glucose-6-phosphate dehydrogenase;
renal / hepatic insufficiency;
- porphyria;
- deep purulent wounds and burns with pronounced exudation;
- Children under 2 years.
Carefully:Renal insufficiency (dose adjustment may be required), hepatic insufficiency, elderly age, bronchial asthma and other allergic reactions in the anamnesis, AIDS (tendency to adverse reactions).
Pregnancy and lactation:Application in pregnancy is possible only in cases where the expected benefit of therapy for the mother exceeds the potential risk to the fetus. In such cases, the drug should be used as short as possible and limited to small areas of skin.
If it is necessary to use lactation, breastfeeding should be discontinued.
The category of FDA recommendations is not defined.
Dosing and Administration:Outwardly. For adults and children over 2 years old, a damaged surface after cleaning the wound is greased with a layer of cream 2 mm 2 times a day; large damaged skin surfaces are covered with a sterile dressing, replaceable 2 times a day, in serious cases up to 4 times. When changing dressings, pain effects are not observed. Before each re-application it is necessary to remove the previous layer of the preparation with a water jet or antiseptic solution. The course of treatment continue until healing.
Side effects:Burning, itching, brownish-gray coloration of the skin, skin allergic reactions (skin rash, photosensitivity); with long-term use on large wound surfaces - systemic side effects (leukopenia, headache, dyspepsia).
Interaction:H2-gistaminoblokatory - increases the risk of developing leukopenia.
Special instructions:Silver salts, reacting with air oxygen, metals and other chemical components, especially with catalyzing thermal effects, darken, so the drug should be stored in a closed container and away from heat sources.Parts of the body treated with the drug are recommended to protect from direct sunlight.