The frequency of side effects is given in accordance with the following gradation: very often:> 10%; often:> 1% and <10%; infrequently:> 0.1% and <1%; rarely:> 0.01% and <0.1%; very rarely: <0.01%.
On the part of the organs of hematopoiesis: rarely - leukopenia, neutropenia, thrombocytopenia.
From the side of the cardiovascular system: often - orthostatic hypotension, tachycardia; infrequently - bradycardia, palpitations, myocardial infarction, lengthening of the interval QT, heart failure, hemorrhages, atrial fibrillation, heart failure, atrioventricular blockade, myocardial ischemia, deep vein thrombosis, phlebitis, extrasystole; rarely - vasovagal syndrome, atrial flutter, supraventricular tachycardia, ventricular tachycardia, thrombophlebitis, intracranial hemorrhage, cerebral ischemia; rarely - fainting, high blood pressure (BP); frequency is not defined - thromboembolism (including pulmonary embolism and deep vein thrombosis of the lower extremities).
From the nervous system: Often - Insomnia, drowsiness, headache, akathisia (in patients with bipolar disorder and in the treatment of depression in combination with antidepressants); often - dizziness, tremor, extrapyramidal syndrome, psychomotor agitation, depression, nervousness, hostility, suicidal thoughts, manic thoughts, confusion, resistance to the implementation of passive movements ("cogwheel" syndrome), lethargy, decreased concentration, sedation; infrequently - dystonia, muscular twitching, paresthesia, tremor of the extremities, bradykinesia, decreased / increased libido, impotence, panic reactions, apathy, memory loss, stupor, amnesia, stroke, hyperactivity, depersonalization, dyskinesia, restless legs syndrome, myoclonus, depressed mood, increased reflexes, slowing of mental function, increased sensitivity to irritants, violation of oculomotor reaction; rarely - delirium, euphoria, bucco-glossal syndrome, akinesia, depression of consciousness (down to loss of consciousness), decreased reflexes, obsessive thoughts, malignant neuroleptic syndrome; rarely - Speech disorder, convulsions.
From the digestive system: Often - nausea, loss of appetite; often - increased appetite (in the treatment of depression in combination with antidepressants), indigestion, vomiting, constipation, hypersecretion of saliva, dry mouth, abdominal heaviness, diarrhea; infrequently - gastroenteritis, difficulty swallowing, flatulence, gastritis, dental caries, gingivitis, hemorrhoids, gastro-esophageal reflux disease, gastrointestinal hemorrhage, periodontal abscess, swelling of the tongue, faecal incontinence, colitis, rectal hemorrhage, stomatitis, ulceration of the oral mucosa, cholecystitis, fecaloma, candidiasis of the oral mucosa, belching, stomach ulcer; rarely - esophagitis, bleeding gums, inflammation of the tongue, vomiting blood, gastrointestinal bleeding, duodenal ulcer, cheilitis, liver enlargement, perforation of the intestine; rarely - Hepatitis, jaundice, pancreatitis, dysphagia, increased activity of ALT and ACT.
From the immune system: rarely - allergic reactions (including anaphylaxis, angioedema, pruritus and urticaria), laryngospasm.
From the side of the musculoskeletal system: often - arthralgia, muscle rigidity; infrequently - myasthenia gravis, arthritis, arthrosis, muscle weakness, muscle spasms, bursitis; rarely - increase in activity of creatine phosphokinase, rhabdomyolysis, tendonitis, tenobursitis, myalgia.
Respiratory system: often - shortness of breath, pneumonia; infrequently - nosebleeds, hiccough, laryngitis; rarely - hemoptysis, increased sputum discharge, dry nasal mucosa, pulmonary edema, pulmonary embolism, hypoxia, respiratory insufficiency, apnea; rarely aspiration pneumonia.
From the skin and subcutaneous tissue: often - dry skin, itching, skin ulceration; infrequently - acne, vesicle-bullous rash, eczema, alopecia, psoriasis, seborrhea; rarely - maculopapular rash, exfoliative dermatitis, hives, hyperhidrosis.
From the sense organs: often - blurred vision, photophobia, pain in the ears; infrequently - dry eyes, pain in the eyes, ringing in the ears, inflammation of the middle ear, cataracts, loss of taste, blepharitis, edema of the eyelids, photopsy, diplopia; rarely - increased lacrimation, frequent blinking, otitis externa, amblyopia, deafness, intraocular hemorrhages.
From the genitourinary system: infrequently - cystitis, frequent urination, leukorrhea, hematuria, dysuria, amenorrhea,impotence, premature ejaculation, vaginal bleeding, vaginal candidiasis, renal failure, uterine bleeding, menorrhagia, albuminuria, nephrolithiasis, nocturia, polyuria, false urges to urinate; rarely - pain in the mammary gland, cervicitis, galactorrhea, anorgasmia, burning in the urethra and external genital tract, glycosuria, gynecomastia (enlargement of the mammary glands in men), painful erection; rarely - urinary incontinence, urinary retention, priapism.
Common violations: often - asthenia, fatigue, flu-like syndrome, sensation of trembling in the body; infrequently: peripheral edema, edema of the face, malaise, photosensitivity, pain in the jaw, stiffness of the jaws, chills, bloating, tension in the chest; rarely - sore throat, stiffness in the back, heaviness in the head, candidiasis, Mendelssohn's syndrome, a feeling of "lump" in the throat, heat stroke; rarely - violation of the regulation of body temperature (including hyperthermia), pain in the chest, in the neck.
Metabolic disorders and disorders associated with diet: often - decreased body weight; infrequently - Dehydration, edema, hypercholesterolemia, hypokalemia, hyperlipidemia, hypoglycemia, thirst, increased urea concentration in the blood, increased activity of alkaline phosphatase, lactate dehydrogenase, iron deficiency anemia, obesity; rarely - Hyperkalemia, hypernatremia, gout, cyanosis, lower urinary pH; rarely - hyponatremia, increased activity of alanine aminotransferase, increased activity of aspartate aminotransferase, increased activity of creatine phosphokinase, anorexia, hyperglycemia, diabetic ketoacidosis, diabetic hyperosmolar coma.
Adverse events occurring with the administration of antipsychotics have also been observed with aripiprazole therapy, including rare cases of malignant neuroleptic syndrome, as well as infrequent cases of late dyskinesia and convulsive seizures.
Individual sensitive patients in the first days of treatment may have symptoms of dystonia manifested by spasm of the neck muscles, with a feeling of constriction in the throat, difficulty in swallowing, difficulty breathing, and / or protrusion of the tongue. These symptoms are most often manifested when high doses of antipsychotics of the firstgeneration. To the group of increased risk for the development of dystonia are men and young people.