Arthra® MSM forte (ARTRA® MSM Forte)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbsp
film coated tablets

Composition:

One tablet, film-coated, contains:

Active substances:

Chondroitin sodium sulfate 400 mg

Glucosamine hydrochloride 500 mg

Methylsulfonylmethane1 300 mg

Sodium hyaluronate (in terms of hyaluronic acid) 10 mg

1 - Commonly accepted abbreviation (synonym) of MSM.

Excipients: cellulose microcrystalline 199.4 mg, calcium hydrophosphate dihydrate 119.6 mg, stearic acid 48 mg, croscarmellose sodium 50 mg, magnesium stearate 10 mg, silicon dioxide colloid 4 mg.

Sheath: opadrai II orange (hypromellose 17.56 mg, polydextrose 7.92 mg, titanium dioxide dye (E171) 0.44 mg, talc 7.88 mg, maltodextrin 4.68 mg, medium chain length triglycerides 0.60 mg, dye solar sunset yellow aluminum lacquer (E110) 0.92 mg) 40 mg.

Description:Tablets are oval, biconvex, covered with a film membrane from light yellow orange to dark orange color. A specific odor is allowed.
Pharmacotherapeutic group:Regeneration of tissue stimulant
Pharmacodynamics:

Components have the ability to inhibit progression osteoarthrosis. Suppresses destruction and stimulates the regeneration of cartilaginous tissue. The drug has anti-inflammatory and analgesic effect.Improves blood flow in the subchondral bone. Reduces the need for nonsteroidal anti-inflammatory drugs (NSAIDs).

Glucosamine and chondroitin sulfate take part in the synthesis of connective tissue. The introduction of exogenous glucosamine enhances the production of the cartilaginous matrix and provides non-specific protection against chemical damage to the cartilage.

Chondroitin sodium sulfate serves as an additional substrate for the formation of a healthy cartilage matrix. Stimulates the formation of hyaluronan, the synthesis of proteoglycans and collagen type II, and also protects hyaluronan from enzymatic cleavage (by suppressing the activity of hyaluronidase) and the damaging effect of free radicals; maintains the viscosity of the synovial fluid. Hyaluronic acid - polysaccharide group of acidic glycosaminoglycans, is an important component of the synovial fluid, determining its viscoelastic properties. It forms on the entire inner surface of the covering layer, which protects articular cartilage and synovial membrane from mechanical damage, as well as free radicals and inflammation factors.

Methylsulfonylmethane (MSM) is an organic sulfur-containing compound.It is a key metabolite of dimethylsulfoxide (DMSO). Contains 34% of natural sulfur. MSM is a part of many endogenous proteins (including connective tissue proteins - collagen, elastin, keratin), hormones and other metabolically active compounds. MSM has an anti-inflammatory and analgesic effect.
Pharmacokinetics:

Bioavailability of glucosamine with oral administration is 25% (the effect of "first passage" through the liver). Distributed in tissues: the highest concentrations are found in the liver, kidneys and articular cartilage. About 30% of the dose is persistently persistent in bone and muscle tissue. It is excreted mainly by the kidneys in an unchanged form; partially - the intestine.

Concentration in the plasma of chondroitin sulfate: once taken at a dose of 0.8 g (or twice a day at a dose of 0.4 g) sharply increases for 24 hours. Absolute bioavailability is 12%. About 10% and 20% of the accepted dose is absorbed in the form of high-molecular and low-molecular derivatives, respectively. It is metabolized by desulfurization. It is excreted in the urine. T1 / 2 - 310 min.

In the experimental models, a certain bioavailability of hyaluronic acid in oraladministered.

Indications:

Osteoarthritis of peripheral joints. Osteocondritis of the spine.

Contraindications:

Hypersensitivity to the components of the drug, pregnancy, lactation, children under 15 years.

Carefully:With caution: a violation of blood clotting, diabetes mellitus, bronchial asthma, intolerance to seafood (shrimp, shellfish).
Pregnancy and lactation:

The drug is contraindicated in pregnancy and during breastfeeding.

Dosing and Administration:

Before using the drug is recommended to consult with a doctor. The drug is taken orally. Adults and children over 15 years of age take 1 tablet 2 times a day during the first three weeks of treatment, then 1 tablet once a day during the course of treatment, which is at least three months.

Side effects:Allergic reactions; pain in epigastrium, flatulence, diarrhea, constipation, nausea, vomiting.
Overdose:

Cases of overdose are not known. In the case of taking large amounts of the drug (more than 10 capsules), there may be nausea, vomiting, diarrhea, hemorrhagic eruptions. Treatment is symptomatic: gastric lavage.

Interaction:Increases the absorption of tetracyclines, reduces the effect of semisynthetic penicillins. The drug is compatible with NSAIDs (non-steroidal anti-inflammatory drugs) and GCS (glucocorticosteroids). It is possible to increase the effect of indirect anticoagulants, antiplatelet agents, fibrinolytic agents.
Special instructions:

It is not recommended for children under 15 years of age due to a lack of scientific data for this category of patients.

Effect on the ability to drive transp. cf. and fur:Does not affect the driving of cars and the management of other mechanisms.
Form release / dosage:Film coated tablets
Packaging:

For 30, 60 or 100 tablets, film-coated in a bottle of polyethylene with a screw cap made of the same material and a safety valve made of foil. The label is attached to the bottle, the bottle is tightened with a polyethylene film and, together with the instruction for use, is placed in a cardboard box.

10 or 15 tablets, film-coated in an aluminum foil / PVC blister. 2, 3, 4, 6, 9, 10 blisters together with instructions for use are placed in a cardboard box.

Storage conditions:In a dry place, at a temperature of 10 - 30 ° C. Keep out of the reach of children.
Shelf life:3 years. Do not use after the expiration date.
Terms of leave from pharmacies:Without recipe
Registration number:LP-001437
Date of registration:17.01.2012 / 10.07.2017
Expiration Date:Unlimited
The owner of the registration certificate:Unipharm, Inc.Unipharm, Inc. USA
Manufacturer: & nbsp
Representation: & nbspUNIFARM, Inc. UNIFARM, Inc. USA
Information update date: & nbsp09.10.2017
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