Chondroitin sulfate - instructions for use, dose, side effects, contraindications

It is the main component of proteoglycans, which together with collagen fibers constitute the matrix of cartilage. It acts as a chondroprotector, suppresses the activity of enzymes that promote degradation of the cartilaginous surface of the joint, activates metabolism in the subchondral bone, stimulates the production of proteoglycans by chondrocytes, and regenerates cartilage tissue. Has analgesic and anti-inflammatory effect, inhibits the secretion of prostaglandin E₂ and leukotriene B₄, reduces the excretion of inflammatory mediators in the synovial fluid.

Prevents the collapse of connective tissue, promotes the restoration of articular surfaces, improves the production of intraarticular fluid, which improves mobility in the joint and reduces the intensity of pain.

Pharmacokinetics:After oral administration, up to 13% is absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is achieved in 3-4 hours.After intramuscular injection - after 1 hour. After 4-5 hours, it accumulates in the synovial fluid.

The half-life is 68 hours, with intramuscular injection - 24 hours. Elimination by the kidneys and with feces.

Indications:It is used for the treatment of osteoarthritis of the joints and spine. Used for fractures to accelerate the formation of bone callus. It is used in dentistry with periodontitis.

ICD-10

XI.K00-K14.K05.2 Acute periodontitis

XI.K00-K14.K05.4 Periodontal disease

XI.K00-K14.K05.3 Chronic periodontitis

XIII.M15-M19 Osteoarthritis

XIII.M15-M19.M19 Other arthrosis

XIII.M20-M25.M25.9 Disease of joint, unspecified

XIII.M80-M85.M80 Osteoporosis with pathological fracture

XIII.M80-M85.M81.8 Other osteoporosis

XIII.M80-M85.M81 Osteoporosis without pathological fracture

XIII.M40-M43.M42 Osteocondritis of the spine

Contraindications:Thrombophlebitis, individual intolerance.

Carefully:Pregnancy and lactation period, children's age, hypersensitivity.

Pregnancy and lactation:

Recommendations for FDA - Category C. It is used with caution during pregnancy and lactation in cases where the intended benefit exceeds the risk to the fetus and newborn.

Dosing and Administration:

Use in children

Inside, depending on age:

up to 1 year: 250 mg per day;

1-5 years: 500 mg per day;

over 5 years: 500-750 mg per day.

Adults

Inside, 750 mg twice a day for 3 weeks, then 500 mg 2 times a day.

Intramuscularly: 100 mg every other day, after the third injection, the dose increases to 200 mg, the course of treatment - up to 25-35 injections.

Outer: 2-3 times a day is applied to the lesion, rubbing it until it is completely absorbed.

The highest daily dose: 1.5 g.

The highest single dose: 750 mg.

Side effects:Local reactions with intramuscular injection: edema, hyperemia, hemorrhage at the injection site.

Allergic reactions.

Overdose:Cases of overdose are not described.

Treatment is symptomatic.

Interaction:

Strengthens the effect of indirect anticoagulants.

Special instructions:

Do not allow the drug to enter the mucous membranes and open wounds.

Instructions

Chondroitin sulfate (Chondroitini sulfas)