Ascorbic acid (Ascorbic asid)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceAscorbic acid [Ascorbic acid + Sodium ascorbate]Ascorbic acid [Ascorbic acid + Sodium ascorbate]
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  • Ascorbic acid
    pills inwards 
    MARBIOFARM, OJSC     Russia
    • Dosage form: & nbsppills
    Composition:

    One tablet contains: ascorbic acid - 0.200 g and sodium ascorbate 99% TG (having composition for 1 g: sodium ascorbate 990 mg, pectin 10 mg) - 0.3375 g (0.3 g in terms of ascorbic acid).

    Excipients: sucrose (sugar refined sugar), dextrose (glucose), stearic acid, potato starch, black currant flavor.

    Description:

    Tablets white or white with a yellowish or grayish hue of color, flat-cylindrical shape, with a facet, without risks. Presence of inclusions of yellowish color is admissible.

    Pharmacotherapeutic group:Vitamin
    ATX: & nbsp

    A.11.G.A   Ascorbic acid

    Pharmacodynamics:

    Ascorbic acid (vitamin C) refers to vitamins that are indispensable for humans and is not synthesized in the human body, but comes only with food. Ascorbic acid plays an important role in the regulation of oxidation-reduction processes, the biosynthesis of proteins, carbohydrates, hormones, the regulation of blood clotting, tissue regeneration, strengthens the walls of blood vessels, increases the body's resistance to infections and stresses. Forming complexes with iron, ascorbic acid improves its absorption.Smoking and the use of ethanol accelerates the destruction of ascorbic acid, drastically reducing reserves in the body.

    Indications:

    Treatment of hypo- and avitaminosis C.

    Conditions accompanied by an increased need for the body in vitamin C (increased physical and mental stress, recovery period after the illness, overwork, stress, smoking, old age). It is also used in the complex therapy of hemorrhagic diathesis and bleeding, flaccid wounds and fractures.

    Contraindications:

    Hypersensitivity to the components of the drug. Do not administer large doses to patients with high blood coagulability, thrombophlebitis and a tendency to thrombosis, as well as diabetes and conditions accompanied by high blood sugar.

    Pregnancy, lactation. Children under 18 years.

    Carefully:

    Hyperoxaluria, renal failure, hemochromatosis, thalassemia, polycythemia, leukemia, sideroblastic anemia, deficiency glucose-6-phosphate dehydrogenase, sickle-cell anemia, progressive malignant diseases, renal stone disease, oxalosis.

    Pregnancy and lactation:Contraindicated.
    Dosing and Administration:

    The drug is taken after a meal. Tablets must be chewed and washed down with a small amount of water.

    For medicinal purposes with pronounced vitamin deficiency and a long flow of infectious diseases, adults are prescribed 1 tablet 2 times a day. Duration of admission depends on the nature of the disease.

    Side effects:

    Allergic reactions to the drug components are possible: skin rash, skin hyperemia, (including anaphylactic shock).

    With prolonged use of the digestive system: ingestion - irritation of the mucous membrane of the gastrointestinal tract, nausea, vomiting, diarrhea.

    From the urinary system: moderate pollakiuria.

    Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.

    Intensive consumption of tablets (chewing) can cause damage to tooth enamel.
    Overdose:

    Symptoms: long-term use of high doses (greater than 1 g per day) can be headache, increased CNS excitability, insomnia, heartburn, nausea, vomiting, diarrhea, hyperacid gastritis, suppression of pancreatic insular apparatus function (hyperglycemia, glycosuria) hyperoxaluria.

    Reduced permeability of capillaries (possibly deterioration of tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies).In case of side effects it is necessary to stop taking the drug, rinse the stomach, give the patient alkaline drink, adsorbents and consult a doctor. Therapy is symptomatic.

    Interaction:

    Ascorbic acid increases the concentration of benzylpenicillin and tetracyclines in the blood; in a dose of 1 g / day increases the bioavailability of ethinyl estradiol (including that of oral contraceptives).

    Improves the absorption of iron in the intestine (transfers trivalent iron to divalent), reduces the effectiveness of heparin and indirect anticoagulants.

    ASA, oral contraceptives, fresh juices, alkaline drink reduces the absorption and absorption of ascorbic acid. With simultaneous application with ASA, urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by about 30%.

    Increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of kidney acids, increases the excretion of drugs,(including alkaloids), reduces the concentration of oral contraceptives in the blood.

    Increases the total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

    LS quinoline series, salicylates, glucocorticosteroids with prolonged use deplete the stores of vitamin C.

    Special instructions:

    In connection with the stimulating effect of ascorbic acid on the formation of corticosteroid hormones, it is necessary to monitor the kidney function and arterial pressure.

    With prolonged use of large doses, it is possible to suppress the function of the insulin apparatus of the pancreas, so during the treatment it is necessary to regularly monitor the functional capacity of the pancreas.

    Persons with a deficiency of glucose-6-phosphate dehydrogenase should be administered with caution.

    In patients with elevated iron levels in the body, ascorbic acid at minimum doses.

    Currently, the effectiveness of the use of ascorbic acid for preventing SSS and certain types of malignant tumors is not proven.

    Ascorbic acid is not recommended for use with pyorrhea, infectious diseases of gums, hemorrhagic phenomena, hematuria, haemorrhage in the retina of the eye, disorders of the immune system, depression, not associated with vitamin C deficiency. ascorbic acid to patients with rapidly proliferating and intensive metastatic tumors can aggravate the course of the process.

    Ascorbic acid as a reducing agent can distort the results of various laboratory tests (blood glucose, bilirubin, activity of "liver" transaminases and LDH).

    Effect on the ability to drive transp. cf. and fur:Not described.
    Form release / dosage:

    Tablets of 500 mg.

    Packaging:10 tablets are packaged in paraffined paper and labeled, or 10 tablets packed in paraffined paper and wrapped in a paraffined paper label.

    For 300 packages, together with an equal number of instructions for use are laid directly in the shipping container.

    Storage conditions:

    In a dry, dark place at a temperature of 10 ° C to 25 ° C.

    Keep out of the reach of children.

    Shelf life:2 years. Do not use the product after the expiry date printed on the package.
    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-004963/09
    Date of registration:24.06.2009
    Expiration Date:Unlimited
    The owner of the registration certificate:MARBIOFARM, OJSC MARBIOFARM, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp26.09.2017
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