Hypersensitivity, angle-closure glaucoma (mydriatic effect, which leads to an increase in intraocular pressure, may trigger an acute attack), tachyarrhythmia, severe chronic heart failure, coronary artery disease, mitral stenosis, reflux esophagitis, hiatal hernia, pyloric stenosis, hepatic and / or renal failure, intestinal atopy, obstructive bowel disease, paralytic ileus, toxic megacolon, ulcerative colitis, xerostomia, myasthenia gravis, for Derzhko urine or predisposition thereto, diseases accompanied by obstruction of the urinary tract (including bladder neck due to prostatic hypertrophy), toxemia of pregnancy, Down syndrome, cerebral palsy, lactation.