The alkaloid contained in the plants of the Solanaceae family, the blocker of M-cholinergic receptors, binds equally to the m1, m2 and m3 subtypes of muscarinic receptors. Affects both central and peripheral M-holinoretseptory. It also acts (though much weaker) on n-cholinergic receptors. Prevents the stimulating effect of acetylcholine; reduces the secretion of salivary, gastric, bronchial, lacrimal, sweat glands, pancreas. Reduces the tone of the muscles of the internal organs (bronchi, digestive tract, bile duct and gallbladder, urethra, bladder); causes tachycardia, improves AV conductivity.Reduces motility of the gastrointestinal tract, practically does not affect the secretion of bile. It dilates the pupils, hinders the outflow of the intraocular fluid, increases the intraocular pressure, causes paralysis of accommodation. In average therapeutic doses, it has a stimulating effect on the central nervous system and a delayed but prolonged sedative effect; stimulates breathing (high doses - respiratory paralysis). Excites the cerebral cortex (in high doses), in toxic doses causes excitation, agitation, hallucinations, coma. Reduces the tone of the vagus nerve, which leads to an increase in heart rate (with a slight change in blood pressure) and a slight increase in conductivity in the bundle. The effect is more pronounced with initially increased tone of the vagus nerve.
After IV introduction, the maximum effect is manifested after 2-4 minutes, after oral administration (in the form of drops) - after 30 minutes.