Symptoms: bradycardia, arrhythmia, insufficiency blood circulation, lowering blood pressure, hypertensive crisis, respiratory depression, delirium, acute hypoxia.
Treatment: with bradycardia - the introduction of 0.3-0.6 mg of atropine, arrhythmias - correction of the content of gases in the blood, circulatory failure and arterial hypotension - the introduction of plasma or plasma-substituting agents, reducing the depth or cessation of general anesthesia, with hyperthermic crisis - stopping inhalation, increased oxygen supply, administration of antipyretics, correction of water-salt balance disorders and metabolic acidosis, if necessary - dantrolene (1 mg / kg) IV drip and continue the administration until the symptoms of crisis (ma maximum DUTY total dose of 10 mg / kg).
To prevent recurrence of the crisis for 1-3 days after the operation, dantrolen is administered orally or IV (4-8 mg / kg / day in 4 divided doses). Respiratory depression or inadequate ventilation postoperative necessitated dose reduction anesthetic (if it is used), airway and mechanical ventilation. In the case of delirium development, after the withdrawal from general anesthesia, small doses of the narcotic analgesic are administered.