Bebifrin - instructions for use, dose, side effects, contraindications

Phenylephrine hydrochloride is an agonist α1-adrenergic receptors (sympathomimetic), which has a vasoconstrictive effect due to stimulation of α1-receptors in the mucous membranes of the nose, reduces swelling of the mucous membranes and hyperemia of tissues, congestion in the nasal mucosa, and also improves the patency of the nasal airways.

Pharmacokinetics:

With topical application, systemic absorption is low.

Indications:

Symptomatic treatment: to facilitate breathing through the nose for colds, flu, hay fever or other allergic diseases of the upper respiratory tract, accompanied by acute rhinitis or sinusitis.

Contraindications:

Increased individual sensitivity to the components of the drug; diseases of the cardiovascular system (including coronarosclerosis, stenocardia), hypertensive crisis, thyrotoxicosis, diabetes mellitus, simultaneous administration of monoamine oxidase inhibitors (MAO) (and also 2 weeks after their cancellation).

Carefully:

Children under 6 years.

Pregnancy and lactation:

Sufficient experience in the use of the drug during pregnancy is not present.Possible application for the treatment of pregnant and lactating mothers as prescribed by the attending physician if the potential benefit to the mother exceeds the possible risk to the fetus or child.

Dosing and Administration:

Intranasally.

For children aged 0 to 1 year: single dose - 1 drop not more often than every 6 hours. For children aged 1 to 6 years: single dose - 1-2 drops.

For children over 6 years of age and adults: single dose - 3-4 drops.

After use, wipe the dropper dry.

Duration of treatment - no more than 3 days.

Side effects:

Local reactions: sometimes burning, tingling or tingling in the nose.

Systemic effects: headache, dizziness, palpitations, arrhythmia, increased blood pressure, sweating, pallor, tremor, sleep disturbance.

If any of the side effects listed in the manual are aggravated or you notice any other side effects not listed in the instructions, inform the doctor about it.

Overdose:

Data on drug overdose are absent.

Potentially possible symptoms (with systemic absorption): ventricular extrasystole, short paroxysms of ventricular tachycardia, sensation of heaviness in the head and extremities, excessive increase in arterial pressure, agitation.Treatment: intravenous administration of short-acting alpha-blockers (phentolamine) and beta-blockers (in case of rhythm disturbances).

Interaction:

MAO inhibitors (procarbazine, selegin), tricyclic antidepressants, maprotiline, guanedrel, guanethidine increase the pressor effect and arrhythmogenicity of phenylephrine (with systemic absorption).

Thyroid hormones increase (coupled with systemic absorption of phenylephrine) the associated risk of coronary insufficiency (especially in coronary atherosclerosis).

Special instructions:

Children from 0 to 1 year old should be used strictly according to the doctor's prescription and not more often than every 6 hours.

In children, the systemic absorption of phenylephrine and the associated risk of side effects are higher than in adults.

Do not assign phenylephrine patients within 2 weeks after the abolition of MAO inhibitors, as they can increase the severity of adrenergic effects of sympathomimetics and increase the risk of side effects from the cardiovascular system.

The duration of the drug should not exceed 3 days, while maintaining a difficult nasal breathing for further use of the drug should consult a doctor.

To avoid the spread of infection, it is necessary to use the drug individually.

Effect on the ability to drive transp. cf. and fur:

There is no evidence of a negative effect of the drug on the ability to drive and other vehicles. However, when symptoms of side effects of the drug manifest themselves, one should refrain from driving and performing actions that require concentration of attention and speed of psychomotor reactions.

Form release / dosage:

Nasal drops 0,125 %.

Packaging:

For 10 or 15 ml in a plastic bottle with a dropper plastic and a lid with a control of the first opening or in a vial dropper polymer complete with a cap screwed and stopper-dropper.

1 bottle with instructions for use in a pack of cardboard.

Storage conditions:

Store at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

After opening the bottle - 1 month.

Do not use after the expiration date!

Terms of leave from pharmacies:Without recipe

Registration number:LP-004310

Date of registration:24.05.2017

Expiration Date:24.05.2022

The owner of the registration certificate:GROTEKS, LLC GROTEKS, LLC Russia

Manufacturer: & nbsp

GROTEKS, LLC Russia

Information update date: & nbsp22.06.2017

Illustrated instructions

Instructions

Bebifrin (Babyfrin)