The drug reduces the antibacterial activity of sulfonamides.
Amantadine and quinidine increase the effect of the drug.
With the simultaneous use of the drug with opioid analgesics and drugs that depress the central nervous system, it is possible to suppress the central nervous system; with haloperidol and organic nitrates - increased intraocular pressure; with glucocorticosteroids for systemic use - their effect is reduced and the intraocular pressure may increase; with M-holinoblokatorami - increased anticholinergic effect; with furosemide - orthostatic hypotension is possible.
Reserpine, monoamine oxidase inhibitors, guanethidine, antacid agents, ascorbic acid, attapulgite reduce the effect of the drug.
With the simultaneous use of the drug with antihistamines, the antihistamine effect increases; with beta-adrenoreceptor blockers, theirEffect; with hormonal contraceptives - the contraceptive effect decreases; with nonselective inhibitors of the reverse neuronal capture of monoamines - the sedative effect is enhanced.
The drug reduces the effect of non-steroidal anti-inflammatory drugs, griseofulvin, digitoxin, doxycycline, ketoconazole, metoclopramide, metronidazole; increases the effect of indapamide, nizatidine.
With simultaneous use with drugs containing potassium, the formation of ulcers in the intestine.