Bellataminal ® is a combined preparation. Has α-adrenoblocking, m-holinoblokiruyuschee and sedative effect, has antispasmodic properties. The drug reduces the excitability of central and peripheral adrenergic and cholinergic systems of the body,has a calming effect on the central nervous system (CNS), has some antispasmodic effect.
Pharmacological properties of the drug are due to the action of the components that make up its composition.
The belladonna the sum of alkaloids (alkaloids group atropine) has m-anticholinergic and spasmolytic effects. Prevents the stimulating effect of acetylcholine; reduces the secretion of salivary, gastric, bronchial, lacrimal, sweat glands, exocrine function of the pancreas. Reduces the muscle tone of the gastrointestinal tract, bile ducts and gallbladder, but increases the tone of the sphincters; causes tachycardia, improves the atrioventricular conductivity. It dilates the pupils, hinders the outflow of the intraocular fluid, increases the intraocular pressure, causes paralysis of accommodation, etc.
Phenobarbital refers to the barbiturate group. It interacts with the barbiturate site of the benzodiazepine-γ-aminobutyric acid-receptor complex, thereby increasing the sensitivity of γ-aminobutyric acid receptors to γ-aminobutyric acid, opening the neuronal channels for chloride ions, which leads to an increase in their entry into the cell.
Suppresses the sensory areas of the cerebral cortex, reduces motor activity, depresses the cerebral functions, including the respiratory center. Reduces the tone of the smooth muscles of the gastrointestinal tract. Has a sedative effect.
Ergotamine ergot alkaloid. Affects various organs and systems of the body, incl. on the central nervous system; increases the tone of the uterus. It has been established that ergotamine is characterized by α-adrenoblocking activity in combination with a pronounced direct vasoconstrictor effect on the smooth musculature of peripheral vessels and cerebral vessels. In this regard, against the background of the action of ergotamine, in spite of its α-adrenoblocking activity, a tonic effect on the peripheral vessels and vessels of the brain predominates. It has a direct stimulating effect on the smooth muscles of the vessels of the skull, causing their narrowing due to binding to 5-HT1-serotonin receptors, which leads to their activation.