Benzonal (Benzonal)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceBenzobarbitalBenzobarbital
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  • Benzonal
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    MOSCOW ENDOCRINE FACTORY, FSUE     Russia
  • Benzonal
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    TATHIMFARMPREPARATY, JSC     Russia
  • Benzonal
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    Anzhero-Sudzhensky Chemical-Pharmaceutical Plant, LLC    
  • Benzonal
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    UZOLE-SIBERIAN CHEMICAL PLANT, OJSC     Russia
    • Dosage form: & nbsppills
    Composition:

    One tablet contains: active substance - benzobarbital (benzonale) 50 or 100 mg;

    Excipients: potato starch, stearic acid, water-soluble methyl cellulose.

    Description:White tablets are flat-cylindrical with a bevel.
    Pharmacotherapeutic group:Antiepileptic remedy
    ATX: & nbsp

    N.03.A.A   Barbiturates and their derivatives

    Pharmacodynamics:

    Antiepilepticheskoe means, practically does not have a hypnotic effect. Enhances inhibitory GABAergic effects in the central nervous system, especially in the thalamus, the ascending activating reticular formation of the brainstem at the level of intercalary neurons. Reducing the permeability of nerve fiber membranes for Na+, reduces the spread of impulses from the focus of epileptic activity. The effect occurs after 20-60 minutes after oral administration.

    Pharmacokinetics:

    Rapidly metabolized in the body, releasing phenobarbital, which has antiepileptic effect.The connection with plasma proteins is weak. Creates high concentrations in the brain, liver and kidneys. Penetrates through the histohematological barriers and into breast milk. The half-life is 3-4 days. It is excreted by the kidneys, both in an unchanged form, and in the form of metabolites.

    Indications:

    Epilepsy of various genesis, generalized and partial seizures, epileptic syndrome. Focal seizures, including Jackson epilepsy, kozhevnikovskaya epilepsy. Small seizures (without convulsions).

    Contraindications:

    Hypersensitivity, hepatic insufficiency, renal failure, heart failure II-III degree, porphyria, anemia, bronchial asthma, respiratory failure, diabetes mellitus, hyperthyroidism, adrenal insufficiency, hyperkinesia, depressive states (with suicidal attempts), children under 3 years , pregnancy (I and III trimester), lactation period.

    Dosing and Administration:

    Inside, after eating, 3 times a day. Dosing regimen is individual and is prescribed by a doctor.

    Adults: Single dose - 0.1-0.15-0.2 g, the maximum single dose - 0.3 g, the maximum daily dose - 0.8 g. The course of treatment is continuous and long, at least 2 years.

    Children: For children 3-6 years old single dose - 0.025-0.05 g, daily - 0.1-0.15 g; 7-10 years old single - 0,05-0,1 g, daily - 0,15-0,3 g; 11-14 years old single - 0.1 g, daily - 0.3-0.4 g; maximum single dose for older children - 0.15 g; the maximum daily - 0.45 g.

    Side effects:

    Addiction, drug dependency, the syndrome of "cancellation", bronchospasm, reduction in blood pressure, thrombocytopenia, anemia, thrombophlebitis, drowsiness, lethargy, confusion, headache, loss of appetite, difficulty in speech, ataxia, nystagmus, slow mental reactions; allergic reactions.

    Overdose:

    Symptoms: depression of the central nervous system functions (drowsiness, impairment of vision, ataxia, dysarthria, nystagmus) up to coma, depression of the respiratory center, lowering blood pressure, renal dysfunction, headache, severe weakness, an increase or decrease in body temperature, agitation, pupillary constriction, tachy or bradycardia, cyanosis, hemorrhages in the pressure field, lung edema. In chronic intoxication - irritability, weakening the capacity for critical evaluation, sleep disturbances, confusion.

    Treatment: gastric lavage, activated charcoal, symptomatic

    therapy.

    Interaction:

    Enhances the effect of narcotic analgesics, means for general anesthesia, neuroleptics, tranquilizers, tricyclic antidepressants, ethanol, hypnotics, reduces - paracetamol, anticoagulants, tetracyclines, griseofulvin, glucocorticosteroids, mineralocorticoids, cardiac glycosides, quinidine, vitamin D, xanthines.

    Special instructions:

    When switching to treatment with benzonal in patients who have previously taken other barbiturates, sleep disturbance is possible, which is eliminated by the appointment of phenobarbital (0.05-0.1) g or other hypnotics for the night. Currently, the treatment of patients with epilepsy begins with other antiepileptic drugs (valproic acid, carbamazepine and others) with less pronounced side effects. Benzobarbital prescribe, if these funds are not effective, more often as part of combination therapy.

    During treatment, do not consume alcoholic beverages.

    Effect on the ability to drive transp. cf. and fur:

    It is necessary to refrain from potentially dangerous activities that require increased concentration of attention.

    Form release / dosage:

    Tablets 50 mg, 100 mg.

    Packaging:Tablets 50 mg: 10 tablets in a planar cell package.3 or 5 contour squares with instructions for use in a pack of cardboard. Tablets 100 mg: 10 tablets in a planar cell package. 5 contour mesh packages with instructions for use in a pack of cardboard.
    Storage conditions:

    It belongs to the list of potent medicines (list No. 1PKKN).

    In a dry, dark place at a temperature of 18 to 22 ° C.

    Keep out of the reach of children.

    Shelf life:4 years. Do not use after the time specified on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-004407/10
    Date of registration:18.05.2010 / 16.12.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:Anzhero-Sudzhensky Chemical-Pharmaceutical Plant, LLC Anzhero-Sudzhensky Chemical-Pharmaceutical Plant, LLC
    Manufacturer: & nbsp
    Information update date: & nbsp22.01.2017
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