Bifikol (Bificol)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceBifidobacteria bifidum + Intestinal sticksBifidobacteria bifidum + Intestinal sticks
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  • Bifikol
    lyophilizate inwards 
    MICROGEN FGUP Scientific and Production Association     Russia
  • Bifikol
    lyophilizate inwards 
    BIOMED them. I.I.Mechnikova, OJSC     Russia
  • Bifikol
    lyophilizate inwards 
    BIOMED them. I.I.Mechnikova, OJSC     Russia
    • Dosage form: & nbsplyophilizate for the preparation of a suspension for oral administration
    Composition:

    1 dose:

    active substance: not less than 107 live bifidobacteria and not less than 107 live intestinal rods;

    Excipients: components of the protective environment of drying (gelatin, sucrose (sugar), milk).

    Note:

    Contents of the components of the drying medium:

    Gelatin of food, grade K-13 or P-11 - from 1,5 to 3%;

    Sugar white lumpy or Sucrose - from 5 to 10%;

    Milk fat-free - raw materials - from 10 to 25%.

    Description:

    A crystalline or porous mass of beige or whitish-gray color of varying intensity, with a specific odor.

    The drug is a live microbial mass antagonistically active strains of bifidobacteria (Bifidobacterium bifidum 1) and Escherichia coli (Escherichia coli M-17) lyophilized in a culture medium with the addition of a protective sugar-gelatin-lactic drying medium.

    Pharmacotherapeutic group:Eubiotic
    ATX: & nbsp

    A.07.F.A   Antidiarrhoeal preparations of biological origin regulating the balance of intestinal microflora

    Pharmacodynamics:

    The therapeutic effect is due to the antagonistic activity of live bifidobacteria and Escherichia coli against pathogenic and opportunistic microorganisms, including Shigella, Salmonella, Proteus, etc.

    The drug has immunomodulating and adjuvant activity due to bacterial antigens affecting the production of specific and nonspecific, including local, defense factors; stimulates local reparative processes in the intestine.

    Indications:

    Healing after acute intestinal infections in the presence of bowel dysfunction, the isolation of pathogenic bacteria; treatment of chronic colitis of various etiologies against the background of dysbiosis.

    Contraindications:

    - Ulcerative colitis;

    - deficiency of sugarase / isomaltase, lactase, fructose intolerance, lactose, glucose-galactose malabsorption;

    - Children under 6 months.

    Pregnancy and lactation:

    Use during pregnancy and during breastfeeding is possible when the intended benefit to the mother exceeds the possible risk to the fetus and / or the child.

    Dosing and Administration:

    The drug is administered orally from 6 months of age 30-40 minutes before meals.

    The contents of the bottle are diluted with boiled water, cooled to room temperature, at the rate of 5 ml (one teaspoon) per dose of the drug. Preparation of the preparation is carried out as follows: pour the necessary amount of water into a glass (in accordance with the number of doses indicated on the bottle); open the bottle, removing the metal cap and rubber cork; from the glass to transfer a small amount of water to the bottle (up to about 2/3 of the volume of the bottle) and dilute the contents, shaking the bottle. Within 5 minutes a homogeneous opaque suspension of beige or whitish-gray color is formed. All the contents of the vial should be transferred to the same glass and mixed.

    One teaspoon of the drug thus diluted is 1 dose. The diluted drug is not subject to storage.

    When the aftercare of convalescent after acute intestinal infections, dysfunctions of unknown etiology:

    - children from 6 months to 1 year: 3 doses 2 times a day for 10-14 days;

    - from 1 g to 3 years: 5 doses 1-2 times a day for 10-14 days;

    - older than 3 years and adults: 5 doses 2-3 times a day for 14-21 days.

    Treatment of dysbacteriosis, nonspecific and specific chronic colitis and enterocolitis:

    - children from 6 months to 1 year: 3 doses 2 times a day for up to 14 days;

    - from 1 year to 3 years: 5 doses 2 times a day for 14-21 days;

    - older than 3 years and adults: 5 doses 2-3 times a day for up to 3 weeks.

    The size of the daily dose and the duration of treatment is determined by the doctor, depending on the severity, duration of the disease and the severity of dysbiosis.

    If necessary, treatment courses can be repeated, but not earlier than 2 months after the end of treatment with a preliminary control of the intestinal microbiocenosis.

    Side effects:

    In the process of treatment, it is possible to develop mild dyspeptic disorders (abdominal discomfort, bloating, rumbling, eructations), which usually pass on their own and do not require withdrawal of the drug or symptomatic drug therapy.

    Overdose:

    Not registered.

    Interaction:

    It is not recommended simultaneous chemo-and antibiotic therapy because of a possible decrease in the therapeutic effectiveness of the drug.

    Special instructions:

    A drug whose package integrity is impaired, a drug without labeling, a drug with altered physical properties and the presence of foreign impurities is unsuitable for use.

    The diluted drug is not subject to storage.

    In the case of a pronounced reaction to the drug (pain and burning in the abdomen, nausea, vomiting, unstable stools, flatulence), it is advisable to temporarily stop the drug (until symptoms stop) or stop Bifikol treatment (if the above symptoms occur repeatedly).

    Effect on the ability to drive transp. cf. and fur:Not studied.
    Form release / dosage:Lyophilizate for the preparation of a suspension for oral administration.
    Packaging:

    5 doses per vial.

    For 10 bottles in a pack with instructions for use.

    Storage conditions:

    AT According to SP 3.3.2.1248-03, at a temperature from 2 before 8 ° C.

    Keep out of the reach of children.

    Transport conditions:

    In accordance with SP 3.3.2.1248-03, at a temperature of 2 to 8 ° C.

    Shelf life:

    1 year.

    The drug is not eligible for use with expired use.

    Terms of leave from pharmacies:Without recipe
    Registration number:LS-002158
    Date of registration:31.10.2011 / 27.09.2013
    Expiration Date:Unlimited
    The owner of the registration certificate:MICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia
    Manufacturer: & nbsp
    Representation: & nbspMICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia
    Information update date: & nbsp16.02.2017
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