The drug is taken orally after a meal with a sufficient amount of liquid.
Dose is administered individually.
Children from 3 to 5 years: 2 tablets (120 mg) 2 times a day.
Children from 6 to 12 years: 4 tablets (120 mg) or 1 tablet (480 mg) 2 times a day.
When pneumonia - 100 mg / kg / day (of sulfamethoxazole calculation), the interval between receptions - 6 hours treatment - 14 days.
With gonorrhea - 2 g sulfamethoxazole 2 times a day with an interval of 12 hours.
Adults and children over 12 years: 960 mg 2 times a day, with prolonged therapy of 480 mg 2 times a day.Usually the drug is well tolerated.
From the side of the nervous system: headache, dizziness; in some cases - aseptic meningitis, depression, apathy, tremor, peripheral neuritis.
On the part of the respiratory system: bronchospasm, suffocation, cough, pulmonary infiltrates.
From the digestive system: nausea, vomiting, decreased appetite, diarrhea, gastritis, abdominal pain, glossitis, stomatitis, cholestasis, increased activity of 'liver "transaminases, hepatitis, sometimes with cholestatic jaundice gepatonekroz, pseudomembranous enterocolitis, pancreatitis.
Co the sides of the hematopoiesis: leukopenia, neutropenia, thrombocytopenia,
agranulocytosis, megaloblastic anemia, aplastic and hemolytic anemia, eosinophilia, hypoprothrombinemia, methemoglobinemia.
From the urinary system: polyuria, interstitial nephritis, renal dysfunction, crystalluria, hematuria, increased urea concentration, hypercreatininaemia, toxic nephropathy with oliguria and anuria.
From the musculoskeletal system: arthralgia, myalgia.
Allergic reactions include itching, photosensitivity, urticaria, drug fever, rash, erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrosis (Lyell's syndrome), exfoliative dermatitis, allergic myocarditis, fever, angioneurotic edema, hyperemia sclera.
Other: hypoglycemia, hyperkalemia, hyponatremia.
Duration of treatment from 5 to 14 days. In severe and / or chronic forms of infectious diseases, an increase in the single dose per 30-50%.
In case of prolongation of the course of treatment for more than 5 days and / or increasing the dose, hematological control should be performed; in case of a change in the blood picture, folic acid should be prescribed at 5-10 mg per day.
Dosage in patients with renal insufficiency: in patients with creatinine clearance 15-30 ml / min. use half the standard dose; if the creatinine clearance is less than 15 ml / min. it is not recommended to use co-trimoxazole.