Included in the formulation
АТХ:C.05.A.D.03 Benzocaine
Pharmacodynamics:Local anesthetic for superficial anesthesia. Prevents the occurrence of pain in the endings of sensitive nerves and pain impulses along nerve fibers.
Does not have a resorptive effect.
When applied to the oral mucosa, the effect develops after 1 minute.
It is believed that when administered orally benzocaine has an anorexigenic effect, which is probably due to the effect on the mucosa of the gastrointestinal tract.
Pharmacokinetics:Benzocaine is hardly soluble in water, which causes its slow absorption. Like all ether derivatives of para-aminobenzoic acid, it is cleaved by esterase in the blood plasma and in the liver. As a result, paraaminobenzoic acid and ethyl alcohol metabolized to acetylcoenzyme A are formed. Paraaminobenzoic acid is conjugated with glycine or excreted unchanged by the kidneys.
Indications:In the combination therapy for oral administration: anesthesia of mucous membranes for spasms and pains in the stomach (including ulcer disease); increased sensitivity of the esophagus.
As a part of combined therapy for external and topical application: pain with superficial lesions of the skin and mucous membranes, with myositis, diseases of superficial veins, hemorrhoids and perianal cracks.
XI.K20-K31.K25 Stomach ulcer
XI.K20-K31.K26 Duodenal ulcer
XVIII.R10-R19.R10.1 Pain localized in the upper abdomen
XVIII.R50-R69.R52.0 Acute pain
XVIII.R50-R69.R52.2 Another constant pain
Contraindications:Children's age (up to 2 years), pregnancy and lactation, hypersensitivity.
Carefully:When used with external antibacterial agents.
Pregnancy and lactation:The action category for fetus by FDA is C.
In pregnancy, use is only possible if necessary (it is not known whether benzocaine harmful embryonic effects and effects on reproductive capacity).
With caution in the period of breastfeeding (it is not known whether benzocaine in breast milk).
Dosing and Administration:Outwardly, the area of the lesion is applied in the form of 5% ointment, solution, powders. If the hearing aid is inflamed - 4-5 drops into the external auditory canal, followed by a tamponade with cotton cloth, repeat the application (if necessary) every 1-2 hours.
Inside, adults - 0.3 g 3-4 times a day; higher doses for adults: one-time - 0.5 g, daily - 1.5 g. Doses for children - depending on age.
In dentistry. Locally 5-20% solution in oil or glycerin is applied to the oral mucosa, powder or 50-70% paste - for anesthesia of hard tooth tissues.
Side effects:Contact dermatitis and / or hypersensitivity reactions (burning, tingling, itching, erythema, rash, urticaria, edema), persistent decrease in sensitivity at the site of application; rarely, with excessive use - methemoglobinemia (especially in infants and young children).
Overdose:Symptoms: methemoglobinemia, dyspnea, cyanosis, dizziness.
Treatment: symptomatic and intravenous injection of methylene blue.
Interaction:With simultaneous use with analgesics-antipyretics, cholinesterase inhibitors, the action of benzocaine is enhanced.
With simultaneous use with benzocaine, antibacterial activity of sulfonamides decreases.
Special instructions:It should be observed that the used dosage form is in compliance with the indications for use.