Blamaren® (Blemaren®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbsp
Granules for solution for oral administration
Composition:
In 100 g of the drug contains:
Citric acid - 39.90 grams
Potassium hydrogen carbonate - 32.25 g
Sodium citrate - 27.85 g
Excipients: none.
Description:
Coarse-grained white granules with a weak odor.
Pharmacotherapeutic group:Treatment for nephrolithiasis
ATX: & nbsp
  • Drugs for the treatment of nephrourolythiasis
    • Pharmacodynamics:
    Dissolves and prevents the formation of uric acid stones by alkalinizing urine to pH 6.6 - 6.8 (with a pH of 6.6-6.8, urinary salts dissolve greatly). In addition, it reduces the excretion of calcium, improves the solubility of calcium oxalate in urine, inhibits the formation of crystals and, consequently, prevents the formation of calcium oxalate stones.
    Pharmacokinetics:Bioavailability is about 100%. It is excreted by the kidneys.
    Indications:
    - dissolution of uric acid and calcium oxalate stones and prevention of their formation;
    - dissolution of mixed uric acid-oxalate stones (with an oxalate content of less than 25%);
    - alkalinization of urine in people receiving cytotoxic drugs or drugs that increase the excretion of uric acid;
    - symptomatic treatment of porphyria of the skin.
    Contraindications:
    hypersensitivity;
    acute and chronic renal failure;
    metabolic alkalosis;
    - urinary tract infections caused by microorganisms that break down urea;
    urine pH is above 7;
    - the need to comply with a strict salt-free diet (for example, with severe forms of hypertension).
    Dosing and Administration:Granules for solution for oral administration:
    Before ingestion, the granular powder is dissolved in 200 ml of liquid (tea, fruit juices, or alkaline mineral water). The daily dose - 6 - 18 g (2 - 6 measuring spoons). In one measuring spoon, 3 g of granular powder.
    The daily dose is evenly distributed throughout the day and is taken after a meal. The dose is considered correctly selected if the pH during the day is within the range of 6.2 - 7.0 (for dissolution of uric acid stones); 7.5 - 8.5 (for cystine stones); 7.2 - 7.5 (for the treatment of porphyria); at least 7.0 (in the treatment of cytostatics). If the pH value of urine is lower than indicated, the dose should be increased, if higher - reduced. Duration of treatment - 4 - 6 months.
    Efficiency monitoring (urine pH determination) is carried out 3 times a day, before each single dose is taken using indicator paper. The resulting color on paper is compared for 2 minutes with a scale and enter the value in the control calendar.
    In the presence of cystine stones and the treatment of porphyria, a special indicator paper with a pH of 7.2 to 9.7 should be used to monitor the efficacy.
    Side effects:
    Allergic reactions, swelling (sodium retention), metabolic alkalosis, dyspepsia.
    Interaction:
    Simultaneous administration of preparations containing citrates and aluminum can lead to increased absorption of aluminum. The interval between doses of such drugs should be at least 2 hours.
    The effect of cardiac glycosides may be weakened, with their combined appointment with Blamaren, in connection with the presence of potassium in the formulation. Some drugs that lower blood pressure (aldosterone antagonists, potassium-sparing diuretics, angiotensin-converting enzyme blockers), as well as anti-inflammatory non-steroid agents and analgesics can reduce the excretion of potassium. The possibility of simultaneous reception of such funds is established by the doctor.
    Special instructions:
    The average daily dose (12 g of granular powder) contains about 1.5 mg of potassium and 0.9 g of sodium (should be taken into account in patients with a restriction of consumption of table salt).Can be used for chronic kidney failure, not accompanied by a delay of potassium ions. Can be prescribed to patients with diabetes mellitus. When dissolving uric acid stones, the daily dose should not be exceeded, because with increasing pH above 7.0, phosphate precipitation occurs on uric acid crystals, which prevents their further dissolution. During treatment, the intake of foods rich in proteins and purine bases should be restricted, and sufficient fluid intake (at least 1.5-2 liters) should be ensured.
    Form release / dosage:
    Granules for solution for oral administration.
    Packaging:
    For 200 g in a plastic bag. The package, the bag clamp, the measuring spoon, the control calendar, the test paper and the instruction for use are placed in a plastic jar with a screw cap.
    Storage conditions:
    List B. Store at a temperature of no higher than 25 ° C.
    Keep out of the reach of children!
    After opening, protect from moisture!
    Shelf life:
    3 years.
    Terms of leave from pharmacies:On prescription
    Registration number:П N012835 / 02
    Date of registration:20.07.2007
    Expiration Date:Unlimited
    The owner of the registration certificate:Esparma GmbHEsparma GmbH Germany
    Manufacturer: & nbsp
    Representation: & nbspESPARMA GmbH ESPARMA GmbH Germany
    Information update date: & nbsp18.02.2017
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