Side effects are classified by frequency: Very often (≥1/10); often (≥1/100, ≤1/10); infrequently (≥1 / 1,000, ≤1/100); rarely (≥1 / 10,000, ≤1 / 1,000); rarely (≤1/10,000).
From the hematopoiesis: often - anemia, leukopenia, granulocytopenia, thrombocytopenia. Oppression of myelopoiesis is a limiting dose, a side effect. Leukocytopenia is usually observed on day 14, thrombocytopenia - on day 18 after the end of therapy and lasts an average of 1 week. Recovery of blood counts occurs by the 4th week.
On the part of the digestive system: often - nausea, vomiting, decreased appetite, stomatitis. Rarely - diarrhea, increased activity of "liver" enzymes. Very rarely - hepatonecrosis caused by occlusion of intrahepatic veins, possibly with a lethal outcome (as a rule, the syndrome was noted during the second course of treatment). Among his symptoms include fever, eosinophilia, abdominal pain, enlargement of the liver and shock, the severity of which rapidly builds up over several hours or days.
From the urinary system: infrequently - an increase in the content of creatinine and urea in the urine.
From the nervous system: infrequently - headache, blurred vision, confusion consciousness, pronounced drowsiness, convulsions, asthenic syndrome, paresthesia, hypoesthesia of the facial skin.
On the part of the reproductive system: often - amenorrhea, azoospermia.
Allergic reactions: very rarely - skin rash, hyperemia of the skin of the face, febrile syndrome, anaphylactic reactions.
From the skin and skin: rarely - alopecia, hyperpigmentation and skin photosensitization.
Local reactions: infrequent - soreness in the place of injection and along the vein; rarely - with getting the drug under the skin - severe pain, necrosis of surrounding tissues.
Other: infrequently - influenza-like syndrome, attachment of secondary infections, thrombosis hepatic veins, myalgia; at long-term application of increased risk development of neoplasms.