From the hematopoiesis: anemia, leukopenia, granulocytopenia, thrombocytopenia. Oppression of myelopoiesis is a limiting dose, a side effect. Leukocytopenia is usually observed on day 14, thrombocytopenia - on day 18 after the end of therapy and lasts an average of 1 week. Recovery of blood counts occurs by the 4th week.
From the digestive system: nausea, vomiting, decreased appetite, stomatitis; rarely - diarrhea, increased activity of "liver" enzymes. Very rarely, a hepatonecrosis caused by occlusion of the intrahepatic veins, possibly with a lethal outcome (as a rule, this syndrome appeared during the 2nd course of treatment).Among his symptoms include fever, eosinophilia, abdominal pain, enlargement of the liver and shock, the severity of which rapidly builds up over several hours or days. From the nervous system: headache, visual impairment, confusion, marked drowsiness, convulsions, asthenic syndrome, paresthesia, facial hypodeses.
On the part of the reproductive system: amenorrhea, azoospermia.
Allergic reactions: skin rash, hyperemia of the facial skin, febrile syndrome, anaphylactic reactions.
From the skin and skin appendages: rarely - alopecia, hyperpigmentation and skin photosensitization.
Local reactions: soreness in the place of injection and along the vein. If the product gets under the skin - severe pain, necrosis of surrounding tissues.
Other: influenza-like syndrome, attachment of secondary infections, thrombosis of hepatic veins, myalgia. With prolonged use, the risk of developing neoplasms increases.