Decaris - instructions for use, dose, side effects, contraindications

Active substanceLevamisoleLevamisole

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Dekaris

pills inwards

GEDEON RICHTER, OJSC Hungary

Dosage form: & nbsppills

Composition:

Active substance:

One tablet Decaris 50 mg contains 50 mg of levamisole (in the form of 59 mg of levamisole hydrochloride).

One tablet Decaris contains 150 mg of levamisole (in the form of 177 mg of levamisole hydrochloride).

Excipients for tablets 50 mg: corn starch, sodium saccharinate, povidone, talc, apricot flavor, magnesium stearate, dye sunset yellow sunset (E 110).

Auxiliaries for tablets 150 mg: corn starch, lactose monohydrate, sucrose, talc, povidone, magnesium stearate.

Description:

Tablets of 50 mg - Round, flat tablets of light orange color (it is possible presence of impregnations of more dark color) with a weak smell of apricot, with a facet and with dividing on a quarter risks on one side.

Tablets 150 mg - Round, flat tablets of almost white color, with a facet and with an engraving DECARIS 150 on one side.

Pharmacotherapeutic group:Anthelminthic remedy

ATX: & nbsp

P.02.C.E. Derivatives of imidazothiazole

P.02.C.E.01 Levamisole

Pharmacodynamics:The active substance of Decaris - levamisole is an anthelmintic agent. Acting on the ganglion-like formations of nematodes, Decaris causes depolarizing neuromuscular paralysis of the membrane of helminth muscles, blocks succinate dehydrogenase, inhibits fumarate dehydrogenase, disrupting the course of bioenergetic helminth processes.Thus, paralyzed nematodes are removed from the body by normal intestinal peristalsis within 24 hours after taking the drug.

Pharmacokinetics:

Levamisol when ingested at a dose of 50 mg is rapidly absorbed from the digestive tract. The maximum concentration in blood plasma is determined, on average, 1.5-2 hours after taking the drug. Levamisole is subjected to intensive metabolism in the liver, its main metabolites - n-hydroxy-levamisole and its glucuronide.

Elimination time from the body is 3-6 hours. Unchanged, excreted in the urine is less than 5%, with feces less than 0.2% of the administered dose.

Indications:Infections helminths Ascaris lumbricoides, Necator Americanus and Ancylostoma duodenale.

Contraindications:

Hypersensitivity to one of the components of the drug; agranulocytosis caused by drugs (in the anamnesis); children under 3 years; lactation period.

For 150 mg tablets, children's age is a contraindication!

Carefully:

Accept carefully with hepatic and / or renal failure, oppression of bone marrow hematopoiesis.

Pregnancy and lactation:

Pregnancy

Pregnant drug should be prescribed only if the expected benefit exceeds the possible risk of using the drug.

Lactation period

To protect the newborn, it is necessary to decide whether to stop breastfeeding or stop taking the drug, depending on how much it is necessary to take the drug for the mother.

Dosing and Administration:

Tablets 50 mg:

Children from 3 to 6 years (10-20 kg) - 25-50 mg (1 / 2-1 tablet); from 6 to 10 years (20-30 kg) 50-75 mg (1- 1.5 tablets); from 10 to 14 years (30-40 kg) - 75-100 mg (1.5-2 tablets) once.

The drug should be taken after a meal with a little water, in the evening.

There is no need for laxatives or special diets. If necessary, taking the drug can be repeated after 7-14 days.

150 mg tablets

Adults once a single tablet of 150 mg is prescribed. The drug should be taken after a meal with a little water, in the evening. There is no need for laxatives or special diets. If necessary, taking the drug can be repeated after 7-14 days.

Side effects:

Headache, insomnia, dizziness, palpitations, seizures, dyspepsia, such as nausea, vomiting, abdominal pain, diarrhea.

There are reports of the development of phenomena from the side of the central nervous system (encephalopathy) 2-5 weeks after taking the drug, as well as allergic reactions (skin rash), convulsions.

In most patients, this phenomenon was reversible, and early use of glucocorticosteroid therapy improved the prognosis.

The connection of these symptoms with the reception of Decaris is not entirely convincing. When using large doses or with prolonged therapy, leukopenia, agranulocytosis, tremor can be observed.

Overdose:

Symptoms

With the introduction of a large dose of levamisole (over 600 mg), the following signs of intoxication were described: nausea, vomiting, drowsiness, convulsions, diarrhea, headache, dizziness and confusion.

Treatment

In case of accidental overdose - if after taking the drug did not pass much time - you can wash the stomach. It is necessary to monitor vital signs and conduct symptomatic therapy.

If there are signs of an anticholinesterase effect, atropine.

Interaction:

With the simultaneous administration of the drug with alcoholic drinks, disulfiramoid-like phenomena are observed.

Care must be taken when applying Decaris with drugs that affect hematopoiesis.

With the simultaneous administration of the drug with coumarin-like anticoagulants prothrombin time may be prolonged, therefore, it is necessary to adjust the dose of oral anticoagulant.Decaris increases the level of phenytoin in the blood, so when using them at the same time, it is necessary to control the level of phenytoin in the blood. Decaris can not be used simultaneously with lipophilic preparations, such as carbon tetrachloride, tetrachlorethylene, chanopodium oil, chloroform or ether, since its toxicity can increase.

Special instructions:

During and after taking the drug, you can not drink alcohol within 24 hours. It is not proved that levamisole, used as an anthelmintic agent, depresses nervous system.

Effect on the ability to drive transp. cf. and fur:

Due to the fact that when taking the drug may occur transient, mild dizziness should be used with caution when driving a car or when working with mechanisms during the entire course of treatment.

Form release / dosage:Tablets 50 mg, 150 mg.

Packaging:

Tablets 50 mg. 2 tablets in a blister of PVC and aluminum foil. 1 blister with instructions for use in a cardboard box.

Tablets 150 mg. 1 tablet in a blister of PVC and aluminum foil. 1 blister with instructions for use in a cardboard box.

Storage conditions:

At a temperature of 15-30 ° C.

Keep out of the reach of children.

Shelf life:

5 years. Do not use the drug after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:П N014042 / 01

Date of registration:23.09.2008 / 23.09.2008

Expiration Date:Unlimited

The owner of the registration certificate:GEDEON RICHTER, OJSC GEDEON RICHTER, OJSC Hungary

Manufacturer: & nbsp

GEDEON RICHTER, Ltd. Hungary

Representation: & nbspGEDEON RICHTER OJSC GEDEON RICHTER OJSC Hungary

Information update date: & nbsp20.03.2017

Illustrated instructions

Instructions

Dekaris (Decaris)