Intravenous spray, drip-drop or drop introduction, electrophoresis. Dosage is selected individually in accordance with the diagnosis and physiological parameters of the patient.
When there is a violation of capillary blood flow (various forms of shock) intravenously drip or drip-drop injected at a dose of 0.5 to 1.5 liters to stabilize hemodynamic parameters at the life-supporting level. If necessary, the volume of the drug can be increased to 2 liters.
Children with various forms of shock are administered at the rate of 5-10 ml / kg, the need - up to 15 ml / kg. It is not recommended to reduce the hematocrit value below 25%.
In cardiovascular and plastic surgery, intravenously drip, immediately before surgery, for 30-60 minutes to adults and children at a dose of 10 ml / kg; during surgery, adults - 500 ml, children - 1.5 ml / kg. After the operation, the drug is administered intravenously drip (within 60 minutes) for 5-6 days at the rate of: adults - 10 ml / kg, children up to 2-3 years - 10 ml / kg 1 time per day, children under 8 years - 7 -10 ml / kg 1-2 times a day, children under 13 years - 5-7 ml / kg 1-2 times a day; for children over 14 years of age, the doses are the same as for adults.
In operations with artificial circulation, the drug is added to the blood at a rate of 10-20 ml / kg to fill the oxygenator pump.The concentration of dextran in the perfusion solution should not exceed 3%. In the postoperative period, the doses of the drug are the same as for a violation of capillary blood flow.
For the purpose of detoxification, intravenously drip in a single dose of 500 to 1250 ml (in children 5-10 ml / kg) for 60-90 minutes. If necessary, you can pour another 500 ml of the drug in the first day (in children the administration of the drug in the first day can be repeated in the same doses). In the following days, the drug is administered drip, adults in a daily dose of 500 ml, children - at a rate of 5-10 ml / kg. It is jointly advisable to introduce crystalloid solutions (Ringer, Ringer-acetate, etc.) in such quantities as to normalize the water-electrolyte balance (especially important in the treatment of dehydrated patients and after surgical operations); the drug, as a rule, causes an increase in diuresis (a decrease in diuresis indicates dehydration of the body).
In ophthalmic practice, it is used by electrophoresis, which is carried out in a conventional way. The consumption of the drug per 1 procedure is 10 ml. The procedure is carried out once a day, injected both from the positive and from the negative pole. Current density - up to 1.5 mA / cm2. The duration of the procedure is 15-20 minutes. The course of treatment - 5-10 procedures.