Individual, determined by the patient's condition, the value of blood pressure, heart rate, hematocrit.
Intravenous, jet, drip-drop and drip.Doses and the speed of administration of the drug should be selected individually in accordance with the indications and condition of the patient.
Immediately before the use of the drug, with the exception of urgent cases, cutaneous test. To do this, after treatment with ethanol at the injection site in the middle of the inner surface of the forearm, 0.05 ml is injected into the forearm to form a lemon crust. The presence of redness with a diameter of more than 1.5 mm at the injection site, the formation of a papule or the appearance of symptoms of a general reaction of the body in the form of nausea, dizziness, and other manifestations 10-15 min after injection indicate a hypersensitivity of the patient to the drug (risk group).
When using the drug is mandatory bioassays: after slow administration of the first 5 drops of the drug, the transfusion is stopped for 3 minutes, then another 30 drops are added and the infusion is stopped again for 3 minutes. In the absence of a reaction, the administration of the drug continues. The results of the bioassay are necessarily recorded in the medical history.
1. When there is a violation of capillary blood flow (various forms of shock) injected intravenously drip or drip-drop, at a dose of 0.5 to 1.5 liters, until the hemodynamic parameters stabilize.If necessary, the amount of the drug can be increased to 2 liters.
Children with various forms of shock are administered at the rate of 5-10 ml / kg, the dose can be increased if necessary to 15 ml / kg. It is not recommended to reduce the hematocrit value below 25%.
2. With cardiovascular and plastic operations injected intravenously drastically, immediately before surgery, for 30-60 minutes adults and children at a dose of 10 ml / kg, during surgery, adults - 500 ml, children - 15 ml / kg. After the operation, the drug is administered intravenously drip (within 60 minutes) for 5-6 days at the rate of: adults - 10 ml / kg, once for children up to 2-3 years - 10 ml / kg 1 time per day, children up to 8 years of age 7-10 ml / kg 1-2 times a day, children under 13 years - 5-7 ml / kg 1-2 times a day. For children older than 14 years, the doses are the same as for adults.
3. In operations with artificial circulation the drug is added to the blood at a rate of 10-20 ml / kg of the patient to fill the oxygenator pump. The concentration of dextran in the perfusion solution should not exceed 3%. In the postoperative period, the doses of the drug are the same as for a violation of capillary blood flow.
4. With the aim of detoxification injected intravenously drip in a single dose of 500 to 1250 ml (in children 5-10 ml / kg) for 60-90 minutes.If necessary, you can pour another 500 ml of the drug in the first day (in children the administration of the drug in the first day can be repeated in the same doses). In the following days, the drug is administered drip, adults in a daily dose of 500 ml, children - at a rate of 5-10 ml / kg.
It is jointly advisable to introduce crystalloid solutions (Ringer and Ringer-acetate, etc.) in such quantities that normalize the water-electrolyte balance (especially important in the treatment of dehydrated patients and after surgery), the drug usually causes an increase in diuresis (a decrease in diuresis indicates for dehydration of the patient's body).
5. In ophthalmic practice is applied by electrophoresis, which is carried out in a conventional manner. The drug consumption per procedure is 10 ml. The procedure is carried out once a day, injected from both the positive and negative pole. The current density is up to 1.5 mA / cm2.
The duration of the procedure is 15-20 min. The course of treatment consists of 5-10 procedures.