Active substanceSerotoninSerotonin
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  • Dinaton
    solution w / m in / in 
       
  • Dosage form: & nbspsolution for intravenous and intramuscular administration
    Composition:
    Active substance: Serotonin adipate - 10 mg.
    Excipients: unitiol - 1.5 mg, water for injection - up to 1 ml.

    Description:
    A colorless or slightly colored transparent solution with a faint smell of hydrogen sulfide.

    Pharmacotherapeutic group:hemostatic, serotonergic
    ATX: & nbsp

    B.02.B.X   Other haemostatic drugs for systemic use

    B.02   Hemostatic preparations

    Pharmacodynamics:
    Hemostatic and serotonergic. The haemostatic effect of serotonin is due to its ability to increase platelet aggregation and capillary resistance, as well as a reduction in bleeding time. Serotonin causes narrowing of the vessels of the kidneys and has an antidiuretic effect. It binds to serotonin receptors of smooth muscles of internal organs and normalizes its contractile activity (endogenous vasomotorics, peristalsis). The manifestation of the normalization of smooth muscle function is the stabilization of hemodynamics, restoration of motor-evacuation function of the gastrointestinal tract, reduction of local hypoxia.

    Pharmacokinetics:
    In blood plasma quickly deaminated and loses its activity.Has no cumulative effect.

    Indications:
    Functional intestinal obstruction (PKN)
    Hemorrhagic syndrome:
    with Werlhof's disease
    on the background of cytostatics treatment
    in acute, subacute and chronic radiation sickness
    with malignant neoplasms Anemia hypo- and aplastic Thrombocytopenia
    Hemorrhagic vasculitis

    Contraindications:
    Hypersensitivity to any component of the drug, glomerulonephritis (acute and chronic), kidney disease, oligo- and anuria, arterial hypertension, acute thrombosis, angioedema, bronchial asthma, diseases accompanied by hypercoagulability.
    If you have any of these diseases, consult a doctor before taking the drug.

    Pregnancy and lactation:
    In pregnancy, the effect of the drug has not been studied, since the drug is rapidly deaminated in the bloodstream. Breastfeeding is not a contraindication for its use.

    Dosing and Administration:
    For the prevention and treatment of functional intestinal obstruction (PKN): intravenously into the central vein at a rate of 5-10 mg / h, previously dissolving the contents of the ampule (10 mg) in 100-200 ml of physiological saline.When administered to the peripheral vein, 10-20 mg should be dissolved in 200-400 ml of saline. The maximum daily dose can reach 360 mg and above.
    Intravenous: 20 to 50 mg are diluted in 200-400 ml of 0.9% sodium chloride solution; injected dropwise (30 cap / min) 2-3 times a day before the appearance or strengthening of weakened peristalsis and clinical manifestations of recovery of motor and evacuation function of the gastrointestinal tract.
    For the prevention and treatment of hemorrhagic syndrome associated with Verlhof disease, treatment with isotostics. radiation sickness, malignant neoplasms, hypo- and aplastic anemia, thrombocytopenia, hemorrhagic vasculitis begin with intravenous administration, then switch to intramuscular injections. The initial dose is 5 mg; in the absence of side effects, the dose is increased to 10 mg, not more than 15-20 mg / day. The course of treatment - an average of 10 days.
    Intravenous: 5-10 mg of the drug is diluted in 100-150 ml of a 0.9% solution of sodium chloride or in 5-10 ml of a 0.9% solution of sodium chloride, followed by dilution in 100-150 ml of a 5% solution of dextrose (plasma, canned blood) and injected drip (no more than 30 cap / min) no more than 2 times a day.
    Intramuscularly: 5 - 10 mg is diluted in 5 ml of a 0.5% solution of lidocaine; Enter 2 times a day at intervals of not less than 4 hours.

    Side effects:
    From the urinary system: a decrease in diuresis.
    From the digestive system: abdominal pain, nausea, diarrhea.
    From the respiratory system: difficulty breathing.
    From the cardiovascular system: cardialgia, increased blood pressure.
    Other: pain along the vein (with rapid administration), with intramuscular injection - soreness at the injection site, a feeling of heaviness in the occipital region.
    If any of the side effects indicated in the manual are aggravated or you notice any other side effects not listed in the instructions, inform your doctor.
    Precautions for use
    In case of side effects, it is necessary to suspend the drug for 2-3 minutes and continue again at a slower rate.

    Overdose:
    Symptoms: hyperemia of the skin, tachypnea.
    Treatment: no specific treatment is required. It is necessary to suspend the administration of the drug for 5-10 minutes and continue again at a slower rate.

    Interaction:
    Serotonin potentiates the effect of narcotic, hypnotic and analgesic drugs. It is not recommended to co-administer with calcium chloride preparations.
    In the event that you are taking other medicines, be sure to consult a doctor before taking the drug.

    Effect on the ability to drive transp. cf. and fur:
    Information on the adverse effects of serotonin on the ability to control vehicles and mechanisms are absent.

    Form release / dosage:Solution for intravenous and intramuscular injection 10 mg / ml.
    Packaging:
    1 or 5 ml into ampoules of neutral glass. 5 ampoules of 1 ml or 1 ampoule of 5 ml, or 5 ampoules of 5 ml in a contiguous cell pack of a polyvinyl chloride film.
    One contour mesh package together with instructions for use in a pack of cardboard.

    Storage conditions:
    In a dry, protected from light place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

    Shelf life:
    3 years.
    The drug should not be used after the expiry date indicated on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-002272
    Date of registration:05.12.2011
    Manufacturer: & nbsp
    Information update date: & nbsp17.09.2015
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