Serotonin - instructions for use, dose, side effects, contraindications

Clinical and pharmacological group: & nbsp

Coagulants (including clotting factors), hemostatics

Included in the formulation

Dinaton

solution w / m in / in

АТХ:

B.02.B.X Other haemostatic drugs for systemic use

B.02 Hemostatic preparations

Pharmacodynamics:

Hemostatic action is due to narrowing of peripheral vessels, increased platelet aggregation, and shorter bleeding times.

Pharmacokinetics:

In blood plasma deaminated and loses its activity. Has no cumulative effect.

Indications:

Hemorrhagic syndrome (including Werlhof's disease, hypo- and aplastic anemia, thrombocytopenia, hemorrhagic vasculitis); hemorrhagic syndrome on the background of treatment with cytostatic drugs, with malignant neoplasms and other diseases.

ICD-10

XI.K70-K77.K76.2 Centrilobular haemorrhagic necrosis of the liver

XI.K20-K31.K29.0 Acute hemorrhagic gastritis

XI.K20-K31.K22.6 Gastroesophageal-esophageal hemorrhagic syndrome

III.D65-D69.D69.9 Hemorrhagic condition, unspecified

III.D65-D69.D69.8 Other specified hemorrhagic conditions

III.D65-D69.D69 Purpura and other hemorrhagic conditions

III.D65-D69.D68.3 Hemorrhagic disorders due to blood circulating anticoagulants

III.D65-D69 Blood clotting disorders, purpura and other hemorrhagic conditions

II.D37-D48.D47.3 Essential (hemorrhagic) thrombocythemia

I.A90-A99.A99 Viral haemorrhagic fever, unspecified

I.A90-A99.A98 Other viral haemorrhagic fevers not elsewhere classified

I.A20-A28.A27.0 Leptospirosis ictero-hemorrhagic

III.D65-D69.D69.3 Idiopathic thrombocytopenic purpura

III.D65-D69.D69.2 Other non-monocytopenic purpura

III.D65-D69.D69.0 Allergic Purpura

Contraindications:

Hypersensitivity, glomerulonephritis (acute and chronic), kidney disease, oligo-, anuria; arterial hypertension, acute thrombosis, angioedema, bronchial asthma, diseases accompanied by hypercoagulability.

Carefully:

In children, efficacy and safety have not been studied.

Pregnancy and lactation:

The category of FDA recommendations is not defined.

Adequate and well-controlled studies in humans and animals have not been conducted. Lactation is not a contraindication to use.

Dosing and Administration:

With severe bleeding start with iv injection, and when it decreases, go to the / m injections. Initial dose of 5 mg; in the absence of side effects, the dose is increased to 0.01 g. The drug is administered intravenously drip in a dose of 5-10 mg in 100-150 ml of a 0.9% solution of sodium chloride or in 5-10 ml of 0.9% sodium chloride solution, which are then diluted in 100-150 ml of a 5% solution of dextrose, plasma, canned blood.The rate of administration is not more than 30 drops per minute. In / m - 5-10 mg in 5 ml of 0.5% procaine solution 2 times a day with an interval of at least 4 hours.

The daily dose for an adult is 15-20 mg. The course of treatment is about 10 days.

Side effects:

With a quick introduction: pain along the vein.

With the / m introduction: soreness at the injection site, abdominal pain, heart, increased blood pressure, heaviness in the head, difficulty breathing, nausea, diarrhea, decreased diuresis.

Overdose:

Symptoms: skin flushing, tachypnea

Treatment: no specific treatment is required. It is necessary to suspend the introduction of the drug for 5-10 minutes and continue at a slower rate.

Interaction:

Against the background of diosmin, the vasoconstrictor effect is enhanced. Serotonin potentiates the effect of narcotic, hypnotic and analgesic drugs.

Special instructions:

It is not recommended to co-administer with calcium chloride preparations.

Instructions

Serotonin (Serotoninum)