Dorithricin® (Dorithricin®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspLozenges.
Composition:
1 tablet contains:

Active substances:
benzocaine 1.50 mg
benzalkonium chloride 1.00 mg
tirotricin 0.50 mg

Excipients: sorbitol 871.00 mg, talc 80, 00 mg, povidone-25 thousand 10.00 mg, carmellose sodium 10.00 mg, sucrose stearate 20.00 mg, peppermint leaves butter 5.00 mg, sodium saccharinate 1.00 mg
Description:Round tablets of flat-cylindrical shape with a bevel, marked DOR1THR1CIN on one side, white with a mint smell.
Pharmacotherapeutic group:Antiseptic + local anesthetic.
ATX: & nbsp
  • Drugs for the treatment of throat diseases
    • Pharmacodynamics:
    Combined drug, has antiseptic and local anesthetic effect. Reduces irritation and pain in the throat, as well as swelling of the oral mucosa.

    Benzocaine is a local anesthetic, which reduces pain when swallowing, which often accompanies infectious inflammatory processes in the mouth and throat.

    Benzalkonium chloride - an antiseptic, breaks the permeability of the cell membrane of microorganisms and inhibits enzymatic processes, is active against many pathogenic bacteria, certain types of viruses, fungi and protozoa.

    Tirotricin is an antibiotic of local action.It is active against a wide range of gram-positive microorganisms and spirochaetes of the oral cavity. In connection with the special mechanism of action of tirotricin, which is absent in systemic action of antibiotics, there is no cross resistance to the drug.
    Pharmacokinetics:
    Benzocaine is slightly soluble in water, which causes poor absorption of it in the intestine. It is cleaved by enzymes in the blood plasma and in a small amount is metabolized in the liver. It is excreted by the kidneys.

    Benzalkonium chloride is practically not absorbed in the intestine and does not have a resorptive effect. It is excreted by the kidneys.

    Tirotricin - in connection with low systemic absorption there is no data on pharmacokinetics. Does not affect intestinal
    microflora.
    Indications:
    Symptomatic treatment of infectious and inflammatory diseases of the oral cavity and throat, accompanied by pain syndrome:

    - pharyngitis, laryngitis, tonsillitis;

    - inflammation of the gums and mucous membrane of the mouth (gingivitis, stomatitis).
    Contraindications:
    Increased individual sensitivity to benzalkonium chloride, benzocaine, tirotricin, para-aminobenzoic acid, quaternary ammonium compounds,any other component of the drug; hereditary fructose intolerance and glucose / galactose absorption disorder or sugarase / isomaltase deficiency (due to the presence of sucrose in the formulation); fresh wounds in the mouth and throat, including immediately after the maxillofacial operation, dental procedures; children's age till 6 years.
    Pregnancy and lactation:The use of Doritricin® during pregnancy and during breastfeeding is possible only after consulting a doctor to determine whether the expected benefit to the mother is greater than the potential risk to the fetus and the baby.
    Dosing and Administration:Inside. Adults and children older than 6 years, slowly dissolve in the oral cavity 1 tablet every 3 hours. The maximum daily dose is 6 tablets. The course of treatment is 7 days. Increase the course of therapy if necessary - on the advice of a doctor. It is not recommended to eat and chew the chewing gum for 1 hour after applying the drug or until there is numbness in the mouth and throat, as there is a risk of aspiration, and damage to the oral mucosa.If the patient's condition does not improve after 2-3 days of use, the doctor should be consulted.
    Side effects:Allergic reactions, gastrointestinal disorders (nausea, diarrhea) are possible. Allergic reactions: skin itching, skin rash, swelling of the mucous membrane of the mouth and throat, anaphylactic reactions; burning sensation, tingling in the mouth and throat; convulsions, tachycardia, dermatitis. It is possible to reduce the sensitivity of the mucous membrane of the mouth and throat. After topical application, in particular when large wounds are found in the mouth and throat, especially in children, methemoglobinemia may develop, which is manifested by shortness of breath, bluish coloration of the lips and fingers. Tirotricin in the presence of fresh wounds can cause bleeding. Sensitized patients may develop hypersensitivity reactions caused by peppermint oil (including dyspnea). In susceptible patients, allergic reactions are possible, caused by substances that are chemically linked to benzocaine, such as penicillins, sulfonamides, cosmetic sunscreen. If any of the side effects listed in the manual are aggravated,or you notice any other side effects not listed in the instructions, tell your doctor.
    Overdose:In the recommended doses of overdose cases are not described. Accidental administration of large doses of Doritricin® can cause disorders on the part of the digestive system (nausea, vomiting, diarrhea), methaemoglobinaemia (difficulty breathing and bluish skin color). In this case, it is necessary to rinse the stomach, take Activated carbon and see a doctor.
    Interaction:
    The cases of clinically significant interaction of Dorithricin® with other drugs have not been described.
    Special instructions:Information for patients with diabetes: in 1 tablet of the drug the carbohydrate content is ~ 0.07 bread units (XE). Children older than 6 years of use of the drug is recommended only for medical reasons. In severe angina (sore throat accompanied by high body temperature, headache, nausea or vomiting), consult a doctor. With a known hypersensitivity reaction of the skin (allergic contact dermatitis), the use of the drug should be avoided because of the possibility of developing a hypersensitivity reaction.It is necessary to observe the interval for 1 hour between the use of the drug and the use of toothpaste, since it is possible to reduce the antibacterial effect of the drug. Sorbitol can have mild laxative effect.
    Effect on the ability to drive transp. cf. and fur:Does not affect.
    Form release / dosage:
    Lozenges.


    Packaging:10 tablets per blister of PVC film and aluminum foil. For 1 blister, along with instructions for use in a cardboard bundle.
    Storage conditions:At room temperature not higher than 25 ° C in a dry, protected from light place. Keep out of the reach of children!
    Shelf life:
    5 years.

    Do not use after expiry date.
    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-004409/10
    Date of registration:18.05.2010/22.12.2015
    The owner of the registration certificate:Medica Pharma GmbH & Co. KG. KG Medica Pharma GmbH & Co. KG. KG Germany
    Manufacturer: & nbsp
    Representation: & nbspKOSMOFARM LLCKOSMOFARM LLC
    Information update date: & nbsp30.03.2016
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