Drotaverin - instructions for use, dose, side effects, contraindications

Myotropic antispasmodic. The chemical structure and pharmacological properties are close to papaverine, but it has a stronger and longer action. Reduces the flow of calcium ions into smooth muscle cells (inhibits phosphodiesterase, leads to the accumulation of intracellular cAMP). Reduces the tone of the smooth muscles of internal organs and intestinal motility, dilates the blood vessels.Does not affect the autonomic nervous system, does not penetrate the central nervous system.

The presence of direct influence on smooth muscles can be used as an antispasmodic in cases when drugs from the group of m-holinoblockers are contraindicated (closed-angle glaucoma, prostatic hypertrophy).

Pharmacokinetics:When taken orally, absorption is high, the half-absorption period is 12 minutes. Bioavailability is 100%. Evenly distributed in tissues, penetrates smooth muscle cells. The time to reach the maximum concentration is 2 hours. The connection with plasma proteins is 95-98%. It is mainly excreted by the kidneys, to a lesser extent - with bile. Does not penetrate the blood-brain barrier.

Indications:

Prevention and treatment of functional conditions and pain syndrome associated with smooth muscle spasm in chronic gastroduodenitis, cholecystitis, cholelithiasis, postcholecystectomy syndrome, gastric ulcer, spastic colitis. Spasms of peripheral arterial vessels, cerebral vessels, renal-stone disease, algodismornorea.They are used to reduce uterine contractions and to relieve spasm of the cervix during labor and during instrumental research.

Contraindications:

Hypersensitivity to the components of the drug, marked hepatic and renal failure; chronic heart failure, atrioventricular blockade of II - III century, cardiogenic shock, arterial hypotension. This dosage form is not used in children.

Carefully:Pronounced atherosclerosis of the coronary arteries, angle-closure glaucoma, prostatic hyperplasia, lactation period, pregnancy (I trimester).

Dosing and Administration:

Inside, adults - 40-80 mg (1-2 tablets) 2-3 times a day.

Side effects:

Dizziness, palpitation, a feeling of heat, increased sweating, lowering blood pressure, allergic skin reactions.

Overdose:

There may be violations of atrioventricular conduction, decreased excitability of the heart muscle, cardiac arrest and paralysis of the respiratory center.

Interaction:

With simultaneous application drotaverine can weaken the antiparkinsonian effect of levodopa.

Strengthens the action of papaverine, bendazole and other antispasmodics (including m-holinoblokatorov).

Increases the decrease in blood pressure caused by tricyclic antidepressants, quinidine and procainamide.

Reduces the spasmogenic activity of morphine.

Phenobarbital increases the severity of spasmolytic action of drotaverine.

Form release / dosage:Tablets of 40 mg.

Packaging:

For 10, 20 tablets in contour cell packs from a polyvinylchloride film and aluminum foil.

1, 2, 3, 4, 5 contour mesh packages together with instructions for use in a pack of cardboard.

Storage conditions:

In a dry, dark place at a temperature of no higher than 20 ° C.

Shelf life:3 years. Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-005373/07

Date of registration:26.12.2007

The owner of the registration certificate:EVROFARM, CJSC EVROFARM, CJSC Russia

Manufacturer: & nbsp

EVROFARM, CJSC Russia

Information update date: & nbsp16.06.2016

Illustrated instructions

Instructions

Drotaverine (Drotaverine)