Spacovin - instructions for use, doses, side effects, contraindications

Myotropic antispasmodic. The chemical structure and pharmacological properties are close to papaverine, but it has a stronger and longer action. Reduces the flow of calcium ions into smooth muscle cells (inhibits phosphodiesterase, leads to the accumulation of intracellular cAMP). Reduces the tone of the smooth muscles of internal organs and intestinal motility, dilates the blood vessels. Does not affect the autonomic nervous system, does not penetrate the central nervous system.

The presence of direct influence on smooth muscles can be used as an antispasmodic in cases when drugs from the group of M-cholinoblockers are contraindicated (closed-angle glaucoma, prostatic hyperplasia).

Pharmacokinetics:

With parenteral administration, the drug appears in 2-4 minutes. The maximum effect occurs in 30 minutes.

Evenly distributed on the tissues, penetrates into the smooth muscle cells. The connection with blood plasma proteins is 95-98%.

Half-life is 2-4 hours. It is mainly excreted by the kidneys, to a lesser extent with bile. Does not penetrate the blood-brain barrier.

Indications:

- spasm of smooth muscles in chronic gastroduodenitis, chronic cholecystitis, cholelithiasis, postcholecystectomy syndrome, peptic ulcer of stomach and duodenum, cardio and pilorospasm, spastic colitis;

- spasm of peripheral arterial vessels, vessels of the brain;

- renal colic;

- algodismenorea.

To reduce the contractions of the uterus and to relieve cervical spasm during childbirth.

When carrying out instrumental research.

Contraindications:

- hypersensitivity to the components of the drug,

- expressed hepatic, renal, heart failure,

- atrioventricular block II-III degree,

- cardiogenic shock,

- arterial hypotension.

Carefully:Pronounced atherosclerosis of the coronary arteries, prostatic hyperplasia, glaucoma, pregnancy and lactation.

Dosing and Administration:

Intramuscularly or subcutaneously, 2-4 ml (40-80 mg) 1-3 times a day. Duration of treatment is 1-2 weeks. If necessary, prolonged treatment is transferred to taking the drug inside.

In cases where a rapid effect is required, 2-4 ml (40-80 mg) of the drug is injected slowly into 10-20 ml of a 0.9% sodium chloride solution or 5% dextrose solution.

Children under 6 years are usually administered at a dose of 10-20 mg 1-2 times a day, children older than 6 years - in a dose of 20 mg 1-2 times a day.

Side effects:

Dizziness, palpitation, lowering blood pressure, feeling hot, sweating, allergic skin reactions.

With intravenous injection - collapse, atrioventricular blockade, arrhythmias, oppression of the respiratory center. With rapid intravenous injection, nausea and vomiting may occur.

Overdose:

In large doses violates the atrioventricular conduction,reduces the excitability of the heart muscle, can cause heart failure and paralysis of the respiratory center.

Treatment is symptomatic.

Interaction:

With simultaneous application can weaken the antiparkinsonian effect of levodopa.

Strengthens the effect of papaverine, bendazole and other antispasmodics (including M-holinoblokatorov), lowering arterial pressure caused by tricyclic antidepressants, quinidine and procainamide.

Reduces the spasmogenic activity of morphine.

Phenobarbital increases the severity of the spasmolytic effect of drotaverine hydrochloride.

Special instructions:

Effect on the ability to drive transp. cf. and fur:

It is necessary to refrain from driving a car and doing other activities that require a high concentration of attention and speed of psychomotor reactions, within 1 h after parenteral (especially intravenous) administration.

Form release / dosage:

Solution for injection 20 mg / ml.

Packaging:

1 or 2 ml into dark glass ampoules (type I F USA).

5 ampoules per blister AL / PVC.

For 1.5, 10, 15, 20, 25 ampoules or blisters together with the instruction for use are placed in a pack of cardboard.

Storage conditions:

List B.Store in a dry, dark place at a temperature of no higher than 25 ° C. Do not freeze.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:П N014943 / 02

Date of registration:15.12.2008

The owner of the registration certificate:M. J. Biofarm Pvt. Ltd.M. J. Biofarm Pvt. Ltd. India

Manufacturer: & nbsp

M.J. BIOPHARM, Pvt. Ltd. India

Representation: & nbspM.J. BIOFARM Pvt. Ltd. division of the corporation MJ Group M.J. BIOFARM Pvt. Ltd. division of the corporation MJ Group India

Information update date: & nbsp16.06.2016

Illustrated instructions

Instructions

Spacovine (Spacovin)