Possible side effects are given below for the body systems and frequency of occurrence: very often (more than 1/10),often (more than 1/100 and less than 1/10), infrequently (more than 1/1000 and less than 1/100), rarely (more than 1/10000 and less than 1/1000), very rarely (less than 1/10000), frequency unknown (the frequency can not be estimated from available data).
Heart Disease
Often: tachycardia.
Infrequent: the paradoxical intensification of angina attacks.
Vascular disorders
Often: orthostatic hypotension.
Infrequently: collapse (accompanied by bradyarrhythmia and syncope).
Frequency unknown: hypotension.
Disorders from the gastrointestinal tract
Infrequent: nausea, vomiting.
Very rarely: heartburn.
Disturbances from the nervous system
Very often: "nitrate" headache.
Often: dizziness (including postural), drowsiness.
Disturbances from the skin and subcutaneous tissues
Infrequent: skin allergic reactions (including rash), "hot flashes" of blood.
Very rarely: angioedema, Stevens-Johnson syndrome.
The frequency is unknown: exfoliative dermatitis.
General violations and violations at the site of introduction
Often: asthenia.
Other: development of tolerance (including cross-over to other nitrates)] To prevent the development of tolerance, continuous intake of high doses of the drug should be avoided.
For organic nitrates, there have been cases of the development of a marked decrease in blood pressure, accompanied by nausea, vomiting, anxiety, pallor and increased sweating.
Prolonged use of the drug may cause transient hypoxemia due to the relative redistribution of blood flow to hypoventilation alveolar sites (in patients with coronary heart disease - may lead to myocardial hypoxia).