Increases the concentration of dihydroergotamine in the blood plasma.
Reduces the effect of vasopressors.
Barbiturates accelerate metabolism and reduce the concentration of isosorbide-5-mononitrate in blood plasma.
With the combined use of isosorbide-5-mononitrate with antihypertensive agents, vasodilators, antipsychotic agents (antipsychotics), tricyclic antidepressants, procainamide, ethanol, quinidine, beta adrenoblockers, slow calcium channel blockers, ethanol, dihydroergotamine and sildenafil, hypotensive effect may increase.
When combined with amiodarone, propranolol, slow calcium channel blockers (verapamil, nifedipine, etc.), it is possible to increase the antianginal effect.
Under the influence of adrenostimulants, alpha-adrenoblockers (dihydroergotamine, etc.), it is possible to reduce the expression of the antianginal effect (excessive decrease in blood pressure and, as a consequence, coronary perfusion). When combined with m-holinoblokatorami (atropine and others) increases the likelihood of increased intraocular pressure.
Adsorbents, astringents and enveloping agents reduce the absorption of isosorbide mononitrate in the gastrointestinal tract.