Echinacea purpurea rhizome with roots (Rhizomata cum radicibus Echinaceae purpurae)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Other immunomodulators

Included in the formulation
  • Echinacea
    pills inwards 
    NGO Farmvilar, OOO     Russia
    • АТХ:

    L.03.A.X   Other immunostimulants

    Pharmacodynamics:

    Immunostimulating, mitogenic, antiviral effect. Increases the activity of granulocytes, macrophages, stimulates humoral and cellular immunity, increases the production of endogenous interferon.

    Pharmacokinetics:

    Not described.

    Indications:

    Reduced immunity caused by various causes (prolonged antibiotic treatment, systematic cooling, overheating, increased radiation background, antitumor radio and chemotherapy, acute and chronic stress, high physical and neuropsychiatric loads, overfatigue), frequent colds and flu (prevention), acute infectious diseases (prevention and treatment), chronic fatigue.

    ICD-10

    X.J30-J39.J39.9   Disease of upper respiratory tract, unspecified

    X.J30-J39.J39   Other diseases of the upper respiratory tract

    X.J30-J39   Other diseases of the upper respiratory tract

    X.J20-J22.J22   Acute respiratory infection of lower respiratory tract, unspecified

    VIII.H60-H62.H60.3   Other infectious external otitis media

    X.J10-J18.J18   Pneumonia without clarification of the pathogen

    X.J40-J47.J42   Chronic bronchitis, unspecified

    XIV.N30-N39.N39.0   Urinary tract infection without established localization

    XXI.Z20-Z29.Z29.1   Prophylactic immunotherapy

    Contraindications:

    Hypersensitivity to the components of the preparation and plants of the family Compositae; progressive systemic and autoimmune diseases, such as tuberculosis, leukemia, collagen, multiple sclerosis, AIDS or HIV infection; children under 1 year (for oral solution) or up to 4 years (for tablets). Pregnancy, lactation.

    Carefully:

    For forms containing in the composition of ethanol: diabetes mellitus, chronic liver disease, epilepsy, chronic alcoholism, bronchial asthma, children's age (up to 12 years).

    Pregnancy and lactation:

    Category of recommendations for FDA is not defined. Qualitative and well-controlled studies on humans and animals have not been conducted. Do not apply!

    There is no information on the penetration into breast milk. Do not apply!

    Dosing and Administration:

    Echinacea preparations are taken internally. The dose, frequency and duration of application are set individually, depending on the dosage form used.

    Side effects:

    With increased sensitivity to Compositae in some cases, there may be allergic skin reactions that require discontinuation of the drug.

    Overdose:

    Symptoms: nausea, vomiting, diarrhea, insomnia, increased excitability of the nervous system.

    Treatment: symptomatic.

    Interaction:Cephalosporins containing a methylthiotetrazol group (cefamandol, cefaferazone) together with Echinacea containing ethanol, can cause tetur-like reactions (nausea, sweating, headaches, palpitations). Reactions may occur 3 days after the end of cefalosporin treatment.
    Echinacea preparations together with immunosuppressants (azathioprine, basiliximab, ciclosporin, daclizumab, muro-mionab, mycophenolate, tacrolimus) weaken their immunosuppressive effect (do not apply before and after transplantation).
    With the simultaneous use of Echinacea preparations with econazole (vaginal cream), the action of econazole decreases. Simultaneous use is not recommended.
    Special instructions:

    Long-term retention of complaints, shortness of breath, fever, purulent or bloody sputum on the background of infectious diseases of the respiratory tract necessitate a doctor's consultation.

    With the repeated appearance of complaints from the urinary tract, a medical examination and regular medical follow-up are necessary in the future. The presence of fever and the preservation of dysuric complaints (regardless of the presence of blood in the urine) for 5 days require a re-visit to the doctor.

    During the period of application of Echinacea, no other immunostimulating drugs should be prescribed.

    High doses affect the activity of sperm enzymes - reduce mobility by 24-48 hours.

    The application can cause an increase in biochemical parameters: ALT, AST, the number of lymphocytes, the level of immunoglobulin E in serum, ESR, and a decrease in serum ferritin.

    It is necessary to avoid prolonged, more than 8 weeks of using the drug.

    In the case of long-term storage of medicinal forms in the form of aqueous extracts, turbidity may develop, a precipitate consisting of active polysaccharides appears (shake several times before use). Turbidity and flocculent formations do not affect efficiency.

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