Hypersensitivity to the components of the drug and plants of the family of astroids (Compositae); progressive systemic diseases (tuberculosis, leukemia, collagenosis, rheumatism, multiple sclerosis, autoimmune diseases, widespread atherosclerosis); AIDS, HIV infection, immunosuppression (including cytostatic antitumor therapy, organ or bone marrow transplantation in anamnesis); blood diseases (agranulocytosis, leukemia); pregnancy,the period of breastfeeding; age to 18 years; lactose intolerance, lactase deficiency, glucose-galactose malabsorption.