- hypersensitivity to Echinacea purpurea, to other plants of the family Compositae (chamomile, arnica, golden daisy, marigold, etc.), as well as to any other ingredients of the preparation;
- systemic connective tissue diseases, progressive systemic diseases such as tuberculosis, leukemia, common atherosclerosis;
- multiple sclerosis, autoimmune diseases;
- AIDS, HIV infection;
- children's age (up to 12 years).