Inside, regardless of food intake. The daily dose of the drug is divided into two doses in the same dose.
Tablets are taken with a sufficient amount of liquid.
Monotherapy
Adults and teenagers over 16 years of age treatment should begin with a daily dose of 500 mg divided into 2 divided doses (250 mg twice a day). After 2 weeks, the dose may be increased to the initial therapeutic dose of 1000 mg (500 mg twice a day). The maximum daily dose is 3000 mg (1500 mg twice a day).
As part of complex therapy
Children older than 4 years and adolescents 12-17 years old with a body weight of up to 50 kg should begin treatment with a daily dose of 20 mg / kg body weight divided into 2 divided doses (10 mg / kg body weight 2 times a day). A dose change of 20 mg / kg body weight can be performed every 2 weeks until the recommended daily dose is 60 mg / kg body weight (30 mg / kg body weight 2 times a day). With intolerance of the recommended daily dose, it is possible to reduce it.The minimum effective dose should be used.
The physician should prescribe the drug in the most suitable dosage form and dosage, depending on the patient's body weight and the required therapeutic dose.
Children with a body weight of more than 50 kg are dosed according to the scheme given for adults.
Adults and adolescents over 16 years of age with a body weight of more than 50 kg treatment should begin with a daily dose of 1000 mg divided into 2 divided doses (500 mg twice a day). Depending on the clinical response and the tolerability of the drug, the daily dose can be increased to a maximum of 3000 mg (1500 mg twice a day). A dose change of 500 mg 2 times a day can be carried out every 2-4 weeks.
Because the levetiracetam is excreted from the body by the kidneys, when the drug is administered patients with renal insufficiency and elderly patients The dose should be adjusted depending on the amount of creatinine clearance (CC).
The creatinine clearance for men can be calculated from the serum creatinine concentration using the following formula:
KK (ml / min) = [140-years (years) x body weight (kg)] / 72 x QCserum (mg / dL)
The creatinine clearance for women can be calculated by multiplying the obtained value by a factor of 0.85.
Then the QC is adjusted taking into account the body surface area (PPT) according to the following formula:
KK (ml / min / 1.73 m2) = KK (ml / min) / PPT object (m2)
| Renal failure | QC (ml / min / 1.73 m2> | Mode dosing |
| Norm | >80 | from 500 mg to 1500 mg twice a day |
| Latent | 50-79 | from 500 mg to 1000 mg 2 doses per day |
| Compensated | 30-49 | from 250 mg to 750 mg twice daily |
| Intermittent | <30 | from 250 mg to 500 mg twice a day |
| Terminal stage (patients on dialysis *) | - | from 500 mg to 1000 mg once a day ** |
* The first day of treatment is recommended to take a saturating dose of 750 mg.
** After dialysis, an additional 250-500 mg dose is recommended.
Children with renal insufficiency correction of the dose of levetiracetam should be made taking into account the degree of renal failure, using recommendations given for adults.
Patients with impaired hepatic function light and moderate degrees of correction of the dosage regimen is not required. In patients with decompensated impairment of liver function and renal insufficiency, the level of decrease in creatinine clearance may not fully reflect the severity of renal failure. In such cases, when the creatinine clearance is <60 ml / min / 1.73 m2 it is recommended to reduce the daily dose by 50%. The duration of the course of treatment is determined by the doctor.