Adults: initial treatment period: 15 mg / kg body weight / day - single dose; continuous treatment: usually 20 mg / kg body weight / day.
The dose can be increased to 30 mg / kg of body weight per day (but not more than 2.0 g) during the initial treatment period, with relapse of the disease, with the resistance of Koch sticks to other anti-tuberculosis drugs.
Children from the age of 13 prescribe from the calculation of 15-25 mg / kg body weight (but not more than 1.0 g).
The full course of treatment lasts 9 months.
In renal diseases, the dosage of the drug depends on the degree of renal failure, the index of which is the creatinine clearance.
Creatinine clearance (ml / min) | Daily dose |
over 100 | 20 mg / kg bw / day |
70-100 | 15 mg / kg bw / day |
below 70 | 10 mg / kg bw / day |
in hemodialysis | 5 mg / kg bw / day |
on dialysis day | 7 mg / kg bw / day |
In patients who have previously taken drugs with tuberculostatic action, the resistance of bacteria develops more often. In such cases ethambutol should be taken with at least one or two anti-tuberculosis drugs that the patient had not previously taken and against which no bacterial resistance was noted.
In complex therapy with ethambutol, isoniazid, para-aminosalicylic acid (PASC), streptomycin, cycloserine, pyrazinamide and ethionamide.