Side effects of Etide are manifested from the side of the gastrointestinal tract, liver, skin, endocrine and nervous system.
On the part of the gastrointestinal tract: loss of appetite, nausea, vomiting, dry mouth or hypersalivation, a "metallic" taste in the mouth. After the withdrawal of the drug, these phenomena tend to quickly pass.
Often during treatment there is an increase in activity of "liver" transaminases. Rare violations of liver function with signs of hepatitis and jaundice are rare. Hepatotoxicity of the drug depends on the existing violations of liver function, such as liver damage due to alcoholism or after surgery. These side effects are especially noted with combined therapy with isoniazid, rifampicin and pyrazinamide.
Skin reactions are rare, in some cases described pellagrope-like reactions in combination with violations from the central nervous system.
Sometimes there are violations of the endocrine system. Along with the development of hypoglycemia (a decrease in blood glucose less than 50 mg%) in patients with diabetes, described the development of gynecomastia (an increase in mammary glands in men).
Rarely there is a violation of the menstrual cycle and impotence, as well as hypothyroidism (a decrease in thyroid function).
The ethid can sometimes cause disturbances from the peripheral and central nervous systems. In a combination with isoniazid cases of polyneuropathy are described. Taking Etid can cause dizziness, headaches, weakness, impaired concentration, mental disorders. Rarely, optic neuritis, tachycardia. Simultaneous reception of other antituberculosis drugs acting on the central nervous system, such as isoniazid or cycloserine, can lead to an increase in side effects from the central nervous system. The same effect can have a simultaneous reception of alcohol. In some cases, allergic reactions and disorders of the bone marrow are described.