Eufillin - instructions for use, dose, side effects, contraindications

The drug inhibits phosphodiesterase and has the ability to inhibit the transport of calcium ions through the channels of cell membranes. Relaxes the musculature of the bronchi, it relieves bronchospasm. Has a moderate positive inotropic and diuretic effect. Euphyllin dilates the coronary vessels, lowers the pressure in the pulmonary artery system, improves the contraction of the diaphragm, increases mucociliary clearance,inhibits the release of mediators from mast cells, stimulates the respiratory center, increases the adrenaline release of the adrenal glands, inhibits the aggregation of platelets, improves microcirculation.

Pharmacokinetics:

60% of euphillin (in healthy adults) and 36% (in newborns) binds to plasma proteins and is distributed in the blood, extracellular fluid and muscle tissue. Eufillin penetrates the placental barrier, it does not accumulate in adipose tissue. 90% of the drug is metabolized in the liver. Metabolites are excreted by the kidneys, 7-13% of the drug is excreted unchanged. The half-life is for non-smokers from 5 to 10 hours, for children over 10 months from 2.5 to 5 hours. Smoking and alcohol significantly affect the metabolism and release of the drug, particularly among smokers, this period is significantly reduced, and ranges from 4 to 5 hours. Removal of the drug is prolonged in patients with respiratory failure, with hepatic and cardiac failure, with viral infections and hyperthermia.

Indications:

Bronchoobstructive syndrome with bronchial asthma, bronchitis, emphysema, chronic cerebral circulatory insufficiency to reduceintracranial pressure; with chronic heart failure (as part of combination therapy); to improve renal blood flow.

Contraindications:

The drug is contraindicated in severe hypotension, paroxysmal tachycardia, arrhythmia, myocardial infarction with cardiac arrhythmia, epilepsy, hypertrophic obstructive cardiomyopathy, hyperthyroidism, increased sensitivity to the drug.

Carefully:

The drug is prescribed with caution in patients with severe hepatic impairment, gastric ulcer and duodenal ulcer.

Pregnancy and lactation:If it is necessary to prescribe the drug during pregnancy and lactation, it is necessary to compare the expected benefit to the mother and the potential risk to the fetus or newborn.

Dosing and Administration:

Inside adults should be prescribed 0.15 g per reception 1-3 times a day after meals. Children inside should be prescribed at a rate of 7-10 mg / kg per day in 4 divided doses. The duration of the course of treatment is from several days to several months.

Higher doses of euphyllin for adults inside: single 0.5 g, daily 1.5 g.

Higher doses for children: inside a single dose of 7 mg / kg, daily 15 mg / kg.

Side effects:

From the gastrointestinal tract: nausea, vomiting, rarely - erosive and ulcerative lesion, irritation of the mucous membrane, lack of appetite.

From the side of the central nervous system: headache, anxiety, dizziness, rarely - convulsions, nausea, vomiting.

From the cardiovascular system: tachycardia, violation of the heart rate, lowering blood pressure.

Allergic reactions: exfoliative dermatitis, febrile reaction.

Overdose:

When an overdose occurs, palpitations, tremors, hyperventilation, convulsions, a sharp decrease in blood pressure, vomiting.

Treatment of an overdose depends on the clinical picture. For cramping seizures applied diazepam. Do not use barbiturates. At the expressed intoxication (the maintenance of an eufillina more than 50 g / l) the hemodialysis is recommended.

Interaction:

Ephedrine, beta-adrenostimulators, caffeine and Furosemide enhance the effects of the drug. In combination with phenobarbital, diphenin, rifampicin, isoniazid, carbamazepine or sulfinpyrazone, a decrease in the efficacy of euphyllin is observed, which may require an increase in the applied doses of the drug.The clearance of the drug is reduced when it is administered in combination with antibiotics of the macrolide group, lincomycin, allopurinol, cimetidine, isoprenaline, beta-blockers, oral contraceptives, which may require a dose reduction. When used in combination with epoxacin and other fluoroquinolines, the dose of euphyllin is reduced. The drug inhibits the therapeutic effects of lithium carbonate and beta-blockers. The appointment of beta-adrenoblockers interferes with the bronchodilating effect of euphyllin and can cause bronchospasm. Eufillin potentiates the action of diuretics by increasing the glomerular filtration and reducing tubular reabsorption. With caution, Euphyllin is prescribed concomitantly with anticoagulants, with other theophylline derivatives or purine.

Special instructions:Elderly patients are advised to reduce the dose of the drug due to delayed excretion of it from the body. Smoking patients are advised to increase the dose due to accelerated removal of the drug from the body.

Form release / dosage:

Tablets 150 mg.

Packaging:Tablets, 10 tablets per contour cell pack.For 1,2,3,5 or 10 contour squares, together with the instruction for use, is placed in a pack of cardboard.

Storage conditions:

List B. In a dry, the dark place at a temperature of no higher than 25 ° C.

Shelf life:

5 years.

After the expiration date, the drug can not be used.

Terms of leave from pharmacies:On prescription

Registration number:P N002315 / 01-2003

Date of registration:15.12.2008

The owner of the registration certificate:FARMASINTEZ, JSC (Irkutsk) FARMASINTEZ, JSC (Irkutsk) Russia

Manufacturer: & nbsp

FARMASINTEZ, JSC (Irkutsk) Russia

Information update date: & nbsp01.11.2012

Illustrated instructions

Instructions

Eufillin (Euphyllini)