Fenibut - instructions for use, doses, side effects, contraindications

1 tablet contains the active substance: aminophenylbutyric acid hydrochloride 250 mg; auxiliary substances: lactose monohydrate (sugar milk) - 180 mg, potato starch - 62 mg, gelatin - 3 mg, calcium stearate - 5 mg.

Description:

tablets white or white with a slightly yellowish hue of color, flat-cylindrical shape with a facet and a risk.

Pharmacotherapeutic group:nootropic remedy

ATX: & nbsp

N.06.B Psychostimulants and nootropic drugs

Pharmacodynamics:

Nootropic agent facilitates gamma-aminobutyric acid (GABA) -mediated transmission of nerve impulses in the central nervous system (direct effect on GABA -ergic receptors). The tranquilizing effect is combined with the activating effect.It has antioxidant and some anticonvulsant action.

Improves the functional state of the brain due to the normalization of its metabolism. It prolongs the latent period and shortens the duration and severity of nystagmus. Hc affects the cholino- and adrenoreceptors. Reduces vasovegetative symptoms (including headache, sensation of heaviness in the head, sleep disorders, irritability, emotional lability). At the course reception increases physical and mental efficiency (attention, memory, speed and accuracy of sensory-motor reactions).

Reduces the manifestation of asthenia (improves well-being, increases interest and initiative (motivation of activity)) without sedation or arousal.

Helps reduce feelings of anxiety, tension and anxiety, normalizes sleep.

Older people do not cause central nervous system depression, muscle-relaxing aftereffect is most often absent. Reduces the inhibitory effect of ethanol on the central nervous system.

Pharmacokinetics:

Absorption is high, penetrates well into all tissues of the body and across the blood-brain barrier (in the brain tissue penetrates about 0.1 % injected dose of the drug, and in young people and the elderly to a much greater extent). Evenly distributed in the liver and kidneys. Metabolized in the liver - 80-95%, metabolites are pharmacologically inactive. Do not cumulate. After 3 hours begins to be secreted by the kidneys, while the concentration in the brain tissue decreases and is detected for another 6 hours. About 5% is excreted by the kidneys unchanged, partially excreted with bile.

Indications:

Asthenic and anxiety-neurotic states.

Insomnia and nighttime anxiety in elderly patients.

Ménière's disease, dizziness associated with dysfunctions of the vestibular analyzer of various genesis (including with otogenous labyrinthitis, vascular and traumatic disorders).

As part of complex therapy for the relief of psychopathological and somatovegetative disorders with abstinence syndrome.

Contraindications:

Hypersensitivity to the components of the drug, pregnancy, breastfeeding, children under 8 years.

Patients with rare hereditary diseases, such as lactose intolerance, lactase deficiency or glucose-galactose malabsorption should not take the drug (due to the presence of lactose).

Carefully:

Carefully with erosive and ulcerative lesions of the gastrointestinal tract, hepatic insufficiency.

Dosing and Administration:

Inside, regardless of food intake.

Adults prescribe 250-500 mg 3 times a day, if necessary, increase the dose to a maximum of 2.5 g per day.

Children from 8 to 14 years - but 250 mg 3 times a day.

Higher single doses: for adults - 750 mg, for people over 60 years - 500 mg; children from 8 to 14 years-250 mg.

With asthenic conditions according to 1/4 tablets per day, in some cases - up to 250 mg per day for 1-1.5 months.

With insomnia and nighttime anxiety in elderly people - 2-3 times a day for 1/2 pills for 1.5-3 months.

With otogenny maze and Meniere's disease during the exacerbation - but 750 mg 3-4 times a day for 5-7 days, with a decrease in the severity of vestibular disorders - 250-500 mg 3 times a day for 5-7 days and then - p250 mg once a day for 5 days. For mild disease, 250 mg twice a day for 5-7 days, followed by a dose reduction of 250 mg once a day for 7-10 days.

For treatment of dizziness with dysfunctions of the vestibular analyzer of vascular and traumatic genesis - 250 mg 3 times a day for 12 days.

For relief of alcohol withdrawal symptoms during the first days of treatment during the day, 250-500 mg 3 times a day and 750 mg for the night with a gradual decrease in the daily dose to the usual for adults.

Side effects:

Increased irritability, agitation, anxiety, dizziness, headache, drowsiness, nausea (with the first techniques), allergic reactions (skin rash, itching).

Overdose:

Symptoms: severe drowsiness, nausea, vomiting, fatty liver disease (taking more than 7000 mg), eosinophilia, lowering blood pressure, impaired renal function.

Treatment: gastric lavage, reception of activated charcoal, symptomatic therapy.

Interaction:

Extends and intensifies the effect of hypnotics, narcotic analgesics, antiepileptic, antipsychotic and antiparkinsonian drugs.

Special instructions:With prolonged use, it is necessary to periodically monitor the performance of the liver and peripheral blood.

Effect on the ability to drive transp. cf. and fur:

It is necessary to refrain from potentially dangerous activities requiring increased attention.

Form release / dosage:

Tablets 250 mg.

Packaging:

For 10 tablets in a cell outline packaging made of polyvinylchloride film and aluminum foil printed lacquered.

For 1, 2, 3 or 5 contour squares, together with the instructions for use, are placed in a pack of cardboard.

Storage conditions:

In the dark place at a temperature of no higher than 30 ° C.

Keep out of the reach of children.

Shelf life:

3 years. Do not use the product after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LSR-001898/10

Date of registration:12.03.2010

The owner of the registration certificate:ORGANICS, JSC ORGANICS, JSC Russia

Manufacturer: & nbsp

ORGANICS, JSC Russia

Information update date: & nbsp18.11.2014

Illustrated instructions

Instructions

Fenibut (Phenybut)