Active substanceAminophenylbutyric acidAminophenylbutyric acid
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  • Dosage form: & nbsppills
    Composition:

    1 tablet contains

    Active substance: aminophenylbutyric acid hydrochloride 250 mg. Excipients: lactose, calcium stearate, potato starch.

    Description:

    Tablets are white or white with a slightly yellowish hue of color, flat-cylindrical, from risk and facet.

    Pharmacotherapeutic group:nootropic remedy
    ATX: & nbsp

    N.06.B   Psychostimulants and nootropic drugs

    Pharmacodynamics:

    Nootropic agent, facilitates GABA-mediated transmission of nerve impulses in the central nervous system (direct effect on GABA-ergic receptors).The tranquilizing effect is combined with the activating effect. It also has antiplatelet, antioxidant and some anticonvulsant action. Improves the functional state of the brain due to the normalization of its metabolism and influence on the cerebral blood flow (increases volumetric and linear speed, reduces vascular resistance, improves microcirculation, and has antiaggregant effect). It prolongs the latent period and shortens the duration and severity of nystagmus. Does not affect cholino- and adrenergic receptors. Reduces vasovegetative symptoms (including headache, sensation of heaviness in the head, sleep disorders, irritability, emotional lability). At the course reception increases physical and mental efficiency (attention, memory, speed and accuracy of sensory-motor responses).

    Reduces the manifestation of asthenia (improves well-being, increases interest and initiative (motivation of activity)) without sedation or arousal.

    Helps reduce feelings of anxiety, tension and anxiety, normalizes sleep. Older people do not cause central nervous system depression, muscle-relaxing aftereffect is most often absent.Reduces the inhibitory effect of ethanol on the central nervous system.

    Pharmacokinetics:

    Absorption is high, it penetrates well into all tissues of the body and across the blood-brain barrier (about 0.1% of the injected dose penetrates the brain tissue, and to a much greater extent in young and elderly people). Evenly distributed in the liver and kidneys. Metabolized in the liver - 80-95%, metabolites are not pharmacologically active. Not cumulated. After 3 hours begins to be secreted by the kidneys, while the concentration in the brain tissue does not decrease and is detected for another 6 hours. About 5% is excreted by the kidneys unchanged, partially excreted bile.

    Indications:

    - asthenic and anxiety-neurotic states

    - stuttering, tics and enuresis in children

    - Insomnia and nighttime anxiety in the elderly

    - Meniere's disease, dizziness associated with dysfunction of the vestibular analyzer of various genesis; prevention of motion sickness with kinetosis

    - in the complex therapy in the treatment of alcohol withdrawal syndrome, for the relief of psychopathological and somatovegetative disorders.

    Contraindications:

    Hypersensitivity, pregnancy, breastfeeding, children under 8 years. Patients with rare hereditary diseases, such as lactose intolerance, lactase deficiency or glucose-galactose malabsorption should not take the drug (due to the presence of lactose).

    Carefully:

    Carefully with erosive and ulcerative lesions of the gastrointestinal tract, hepatic insufficiency.

    Dosing and Administration:

    Inside after eating 2-3 week courses.

    Adults and children from 14 years to 250-500 mg 3 times a day (maximum daily dose of 1500 mg). Children from 8 to 14 years - 250 mg 3 times a day. A single maximum dose in adults and children from the age of 14 is 750 mg, in people over 60 years - 500 mg, from 8 to 14 years - 250 mg.

    Alcohol withdrawal: 250-500 mg 3 times a day and 750 mg at night, with a gradual decrease in the daily dose to normal for adults.

    Treatment of dizziness with dysfunction of the vestibular apparatus and Meniere's disease: 250 mg 3 times a day for 14 days.

    Prevention of motion sickness: 250-500 mg once for 1 hour before the expected start of the pitching or when the first symptoms of seasickness appear. The anti-sweating effect of Phenibutum increases with an increase in the dose of the drug.At the onset of severe manifestations of seasickness (vomiting, etc.), the administration of phenibutum is ineffective even in doses of 750-1000 mg.

    Side effects:

    Drowsiness, nausea. Enhancement of irritability, agitation, anxiety, dizziness, headache (at the first receptions), allergic reactions.

    Overdose:

    Symptoms: increased severity of side effects; severe drowsiness, nausea, vomiting, fatty liver disease (taking more than 7000 mg), eosinophilia, lowering blood pressure, impaired renal function.

    Treatment: gastric lavage, reception of activated charcoal and conduction symptomatic therapy.

    Interaction:

    Extends and intensifies the effect of sleeping pills, narcotic analgesics, neuroleptics, antiparkinsonian and antiepileptic drugs.

    Special instructions:With prolonged use, it is necessary to periodically monitor the performance of the liver and peripheral blood.
    Effect on the ability to drive transp. cf. and fur:

    It is necessary to refrain from potentially dangerous activities requiring increased attention.

    Form release / dosage:

    Tablets 250 mg.

    Packaging:

    For 10 tablets in a contour mesh box made of PVC film and aluminum foil.

    1 or 2 contour packs together with instructions for use are placed in a cardboard pack.
    Storage conditions:

    List B. In a dry, the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years. Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:П N015655 / 01
    Date of registration:29.05.2009
    The owner of the registration certificate:BELMEDPREPARATY, RUP BELMEDPREPARATY, RUP Republic of Belarus
    Manufacturer: & nbsp
    BELMEDPREPARATY, RUP Republic of Belarus
    Information update date: & nbsp11.08.2009
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