Finalgon® (Finalgon®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceNonivamide + NicoboxylNonivamide + Nicoboxyl
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  • Finalgon®
    ointment externally 
    Boehringer Ingelheim International GmbH     Germany
    • Dosage form: & nbspointment for external use
    Composition:In 1 g of ointment contains:
    nonivamide (vanillic acid vanillylamide) (PSVA)
    4 mg nicoboxyl (butoxyethyl nicotinic acid ester) (NSBE) 25 mg
    Excipients: Diisopropyl adipate (Crodamol) 120 mg; silicon dioxide colloidal 20 mg; Vaseline (paraffin, mild white) 822 mg; sorbic acid 2 mg; citronella oil 2 mg; purified water 5 mg.
    Description:Almost colorless or slightly brownish, transparent or translucent, homogeneous homogeneous ointment.
    Pharmacotherapeutic group:local irritant
    ATX: & nbsp

    M.02.A.X.10   Other drugs

    Pharmacodynamics:Nonivawid
    Is an synthetic analog capsaicin and has analgesics properties that are manifested in gradual penetration substances in the peripheral nociceptive C-fibers and A-delta nerve fibers with repeated application of the preparation to the skin.Nonivamide has a vasodilating effect action, which is accompanied by intense, prolonged sensation heat, through the stimulation of afferent nerve endings in the skin.
    Nicoboxyl
    Is a derivative of nicotine acid with vasodilator properties at participation of prostaglandins I2 and E2. Hyperemic effect of nicoboxyl(butoxyethyl ether of nicotinic acid) develops faster and has greater intensity than hyperemic effect of nonivamide.
    Combined action
    Nonivamide and nicoboxyl possess complementing each other vasodilating properties, cause flushing of the skin, increase the rate of enzymatic reactions, activate metabolism.The appearance of rednessand increase skin temperature for several minutes after application indicate rapid penetration of active components of the drug in the skin. Act FINALGONA manifests itself locally. The action of the drug develops during several min., maximum effect comes in 20-30 minutes. Analgesic the combination of 0.4% nonivamide and 2.5% Nicoboxyl was demonstrated in effectiveness in patients with acute nonspecific pain in the lower back. It was found that in patients, who used FIALALGON (2 cm ointment for one application and applied the drug up to 3 times a day for 4 days),a clinically significant decrease in the intensity of pain in the lower back was observed only 4 hours after the first application; on the last day of treatment, determined individually, a clinically significant reduction in pain was also observed. The clinical study found that the reduction of pain began in 1-2 hours.
    Indications:Arthritis, rheumatic joint pain and muscle, sports injuries, bruises and damage to the ligamentous apparatus, muscle pain caused by excessive physical activity, lumbago, neuritis, sciatica, bursitis, tendovaginitis, acute nonspecific pain in the lower back.
    For preliminary "warming up" of muscles before exercise, sports competitions. In the composition complex vasodilator therapy violations of peripheral circulation.
    Contraindications:- Hypersensitivity to nioboxyl, nonivamide or excipients of the drug.
    - Do not apply ointment on sensitive skin, open wound, inflamed skin, skin areas with increased permeability: the neck, the lower abdomen, inner side of the thighs.
    - Children's age under 18 (due to insufficient data on efficacy and safety for this group of patients).
    Pregnancy and lactation:Special drug studies FINALGON during pregnancy and in the period of breastfeeding was not carried out. Do not use the drug during pregnancy and breastfeeding.
    Studies of the effect of the drug on fertility have not been conducted.
    Dosing and Administration:Treatment it is necessary to begin with drawing a small amount of the drug on small area of ​​skin for evaluation individual reaction. Individual response to the drug can significantly different: some people will it is enough to apply a small amount ointment, in order to induce the necessary heating effect, while in others the heating effect will be insignificant or absent. Begin the application with the smallest dose of the drug. For this, when using the supplied applicator drug size not more than 0.5 cm. is applied to the relevant area skin size palm light rubbing movements. To strengthen the skin which is applied the drug, you can cover woolen cloth.
    With multiple applications, the response to ointment may decrease, which requires increase the dose that is selected individually. Maximum recommended dose of drug application is no more than 1 cm per square the size of the palm (about 10 cm x 20 cm). If necessary, ointment is used up to 3 once a day.
    For preliminary warming up of muscles before physical exercises, sports competitions it is recommended to rub about 30 minutes before they start. If there is no desired effect in For 10 days you should contact a specialist.
    After applying the product on the skin, wash hands thoroughly with soap and water.

    Side effects:During the course of clinical research and long experience application of the drug have been identified following side effects:
    From the immune system: anaphylactic reactions, increased sensitivity.
    From the nervous system: paresthesia, burning sensation.
    On the part of the respiratory system: cough, dyspnea.
    From the skin and subcutaneous tissues: vesicles or pustules at the site of application, erythema, localized skin reaction (eg, contact dermatitis), itching, rash, swelling of the face, hives, a feeling of heat in the place of application.
    Overdose:

    Symptoms

    The effect of skin hyperemia and the severity of dose-dependent side effects can be exacerbated after application excess amount of ointment FINALGON®.

    The use of excessive amounts of the drug can lead to the occurrence of vesicles or pustules at the site of ointment application.

    An overdose of the drug can cause systemic reactions (reddening of the upper body, increased body temperature, "hot flushes" of blood, painful hyperemia, lowering of blood pressure), tk. nicotinic acid esters have good transdermal absorption.

    Treatment

    When using an excessive amount of the drug, the effect can be reduced by removing the ointment from the skin surface with vegetable oil or a cosmetic cream on a fat basis, from the mucous membrane of the eye (in case of accidental ingestion) with the help of medical Vaseline. If necessary, symptomatic treatment should be performed.

    Interaction:Interactions with other drugs, applied locally or systemically, were not identified.
    Special instructions:

    The drug causes flushing of the skin, resulting in redness, a feeling of heat, itching and burning at the site of application. These symptoms can be more pronounced when applying an excessive amount of the drug or in the case of intense rubbing on the surface of the skin. Use of excessive amounts of the drug or intense rubbing on the surface of the skin can lead to the occurrence of vesicles or pustules at the site of application of the ointment. After using Finangel®, wash hands immediately with soap and water. Care must be taken to avoid accidental ingestion of the drug to other areas of the skin or getting the drug on another person.

    Avoid accidental ingestion of the drug on the face, in the eyes, nose or mouth. This can lead to temporary swelling of the face, pain in the face, inflammation conjunctiva, eye hyperemia, burning eyes, visual impairment, discomfort in the oral cavity and stomatitis.

    Before or after application to skin should not be taken hot bath or shower.

    Sweating or heat application place of application cause reddening of the skin and intense feeling of heat even after a few hours after Finangel® application.

    The formulation contains sorbic acid, which can cause local skin irritation (for example, contact dermatitis).

    Effect on the ability to drive transp. cf. and fur:Special clinical studies of the effect of the drug on ability to operate a car and machinery is not was conducted. However, during the application of the drug at control and handling of machinery exercise caution.
    Form release / dosage:

    Ointment for external use.

    Packaging:By 20 g or 50 g in an aluminum tube, covered with a plastic cap with a punch for the membrane. Each tube with a saber and instructions for use is placed in a pack of cardboard.
    Storage conditions:

    At a temperature not higher than 25 ° C, out of the reach of children.

    Shelf life:

    4 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:П N015513 / 01
    Date of registration:27.01.2009
    The owner of the registration certificate:Boehringer Ingelheim International GmbHBoehringer Ingelheim International GmbH Germany
    Manufacturer: & nbsp
    Representation: & nbspBehringer Ingelheim, LLCBehringer Ingelheim, LLC
    Information update date: & nbsp08.08.2015
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