Nonivamide + Nicoboxyl (Nonivamidum + Nicoboxilum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Local irritants

Included in the formulation
  • Finalgon®
    ointment externally 
    Boehringer Ingelheim International GmbH     Germany
    • АТХ:

    M.02.A.X.10   Other drugs

    Pharmacodynamics:

    Nonivamide is a synthetic analog of capsaicin, after local application it gradually penetrates into the peripheral nociceptive Cfibers and A- delta nerve fibers, has analgesic effect.

    Nicoboxyl has a direct vasodilating effect.

    In combination, these two components complement the vasodilating properties of each other, local application of the drug leads to hyperemia, increases metabolism, leads to a local increase in temperature, increase the rate of enzyme reactions.

    Pharmacokinetics:

    The appearance of redness and a rise in skin temperature within a few minutes after application indicate a rapid penetration of the active components of the drug into the skin. The action of the drug appears locally.

    The action of the ointment develops within a few minutes, the maximum effect occurs in 20-30 minutes.

    Indications:

    Lumbago.

    Rheumatic pain in the joints and muscles.

    Ishialgia.

    Tendovaginitis.

    Bursitis.

    Sports injuries.

    Stretching.

    Contusions and damage to the ligamentous apparatus.

    Arthritis.

    Myalgia, caused by excessive physical exertion.

    Arthralgia.

    Violation of perandferric circulation.

    Neuritis.

    ICD-10

    IX.I70-I79.I73.0   Raynaud's syndrome

    IX.I70-I79.I73.1   Obliterating thromboangitis [Berger's disease]

    IX.I70-I79.I73.9   Peripheral vascular disease, unspecified

    XIII.M05-M14.M05   Seropositive rheumatoid arthritis

    XIII.M20-M25.M25.5   Pain in the joint

    XIII.M50-M54.M54.1   Radiculopathy

    XIII.M50-M54.M54.3   Sciatica

    XIII.M50-M54.M54.4   Lumbago with sciatica

    XIII.M65-M68.M65   Synovitis and tenosynovitis

    XIII.M70-M79.M70   Diseases of soft tissues associated with exercise, overload and pressure

    XIII.M70-M79.M71   Other bursopathies

    XIII.M70-M79.M79.1   Myalgia

    XIII.M70-M79.M79.2   Neuralgia and neuritis, unspecified

    XIX.T08-T14.T14.3   Dislocation, stretching and overstrain of the capsular-ligamentous apparatus of the joint of the unspecified area of ​​the body

    Contraindications:

    Dermatosis.

    Hypersensitivity.

    Do not apply to open skin wounds and skin areas with impaired permeability, on the neck, lower abdomen and the inside of the thighs.

    Carefully:

    Avoid getting the drug on the mucous membranes and eyes. Breastfeeding, child age, pregnancy.

    Pregnancy and lactation:

    Category FDA not determined. Qualitative and well-controlled studies on humans and animals have not been conducted. There is no information on the penetration into breast milk.

    Dosing and Administration:

    Locally no more than 0.5 cm on the corresponding skin area. To enhance the therapeutic effect of skin,on which the preparation is applied, can be covered with a woolen cloth.

    To warm up the muscles - rubbed locally for 30 minutes before the start of exercise.

    With repeated use, the reaction to the ointment may decrease, which requires an increase in the dose, which is selected individually. If necessary, ointment is used 2-3 times a day.

    Do not take longer than 10 days without consulting a doctor.

    Side effects:

    Symptoms: the effect of skin hyperemia and the severity of dose-dependent side effects can be exacerbated after applying an excessive amount of ointment. The use of excessive amounts of the drug can lead to the occurrence of vesicles or pustules at the site of ointment application.

    Overdose:

    An overdose of the drug can cause systemic reactions (reddening of the upper body, increased body temperature, blood flushes, painful hyperemia, decreased blood pressure), since esters of nicotinic acid have good transdermal absorption.

    Treatment: when using an excessive amount of the drug, the effect can be reduced by removing the ointment from the skin surface with vegetable oil or a cosmetic cream on a fatty basis,from the mucous membrane of the eye (with accidental ingestion) - with the help of medical Vaseline. If necessary, symptomatic treatment should be performed.

    Interaction:

    Not described.

    Special instructions:

    Patients with sensitive skin should not take a hot shower or bath after applying the drug. After applying the drug, you should wash your hands thoroughly.

    Sweating or the application of heat to the site of application can cause reddening of the skin and intense sensation of heat even a few hours after application of the ointment.

    The drug contains sorbic acid, which can cause local skin irritation (eg, contact dermatitis).

    Avoid accidental ingestion of the drug on the face, eyes, nose or mouth. This can lead to temporary swelling of the face, pain in the face, inflammation of the conjunctiva, eye hyperemia, burning in the eyes, visual impairment, discomfort in the oral cavity and stomatitis.

    Impact on the ability to drive vehicles and manage mechanisms

    Special clinical studies of the effect of the drug on the ability to control the car and mechanisms were not carried out.However, caution should be exercised during the use of the drug when driving and working with machinery

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