Signs of acute poisoning caused by paracetamol - pallor of the skin, decreased appetite, nausea, vomiting, stomach pain, signs of liver damage are determined in 1-2 days. In severe cases, hepatonecrosis develops (the severity of necrosis, due to intoxication directly depends on the degree of overdose), hepatic insufficiency, encephalopathy and coma. Toxic effect in adults is possible after taking more than 10-15 g of paracetamol: increasing the activity of "liver" transaminases, increasing prothrombin time (12-48 hours after administration); a detailed clinical picture of liver damage manifests itself after 1-6 days. Rarely, liver failure develops at a lightning speed and can be complicated by renal insufficiency (tubular necrosis). The effect of caffeine can be manifested by periods of psychomotor agitation, tachycardia, cardiac arrhythmias, elevated diuresis, muscle cramps. Chlorpheniramine may be associated with dizziness, dry mouth, nausea, depression of the central nervous system.
The victim, who took in a short time more than 15 tablets of the drug,should be done rinsing the stomach during the first 4 hours of poisoning, assign adsorbents, introduce agents that increase the formation of glutathione (methionine - 8-9 hours after an overdose, acetylcysteine - in the first 12 hours). Detoxification can be done by hemodialysis. Along with these measures, symptomatic therapy should be provided.